Haataja Paula, Korhonen Päivi, Ojala Riitta, Hirvonen Mikko, Paassilta Marita, Gissler Mika, Luukkaala Tiina, Tammela Outi
Pirkanmaa Hospital District, Department of Pediatrics, Tampere University Hospital, PL 2000, 33520, Tampere, Finland.
Tampere Center for Child Health Research, University of Tampere, Tampere, Finland.
Eur J Pediatr. 2016 Jun;175(6):799-808. doi: 10.1007/s00431-016-2708-8. Epub 2016 Feb 22.
This national register study aimed to evaluate the need of asthma medication reimbursement and hospitalization due to asthma and atopic dermatitis up to 7 years of age in moderately preterm (MP) (32-33 weeks) and late preterm (LP) (34-36 weeks) children compared to very preterm (VP) (<32 weeks) and term (≥37 weeks) children. Altogether, 1,018,302 children born in Finland between 1991 and 2008 were assessed. The MP and LP groups received asthma medication reimbursement more frequently than term controls (8.0 and 5.7 vs. 3.8 %), but less frequently than VP children (15.4 %). Hospitalization due to asthma was more common among MP (10.6 %) and LP (7.3 %) children than term children (4.8 %) but less common than in VP children (20.1 %). Hospitalization due to atopic dermatitis was more frequent among term (5.2 %) compared to MP (4.2 %) and LP (4.7 %) children. Male sex, maternal smoking, maternal diabetes, and ventilator therapy predicted asthma medication in the MP and/or LP children.
MP and LP children seem to need medication and hospitalization for asthma more often than term controls but less frequently than VP children followed by 7 years of age. Hospitalization due to atopic dermatitis becomes more common with increasing gestational age.
• MP and LP infants have an increased risk for early respiratory morbidity and to asthma. • Less is known on the occurrence of atopic dermatitis in this patient group. What is New: • Medication and hospital care due to asthma were more frequent in school-aged MP and LP than in term infants. Male sex, maternal smoking, maternal diabetes and ventilator therapy predicted asthma. • Hospitalization due to atopic dermatitis became more common with increasing gestational age.
本全国性登记研究旨在评估中度早产（MP）（32 - 33周）和晚期早产（LP）（34 - 36周）儿童与极早产（VP）（<32周）和足月儿（≥37周）相比，7岁前因哮喘和特应性皮炎所需的哮喘药物报销及住院情况。共评估了1991年至2008年在芬兰出生的1,018,302名儿童。MP组和LP组接受哮喘药物报销的频率高于足月儿对照组（分别为8.0%和5.7%，而对照组为3.8%），但低于VP组儿童（15.4%）。MP组（10.6%）和LP组（7.3%）儿童因哮喘住院的情况比足月儿（4.8%）更常见，但比VP组儿童（20.1%）少见。与MP组（4.2%）和LP组（4.7%）儿童相比，足月儿（5.2%）因特应性皮炎住院的情况更频繁。男性、母亲吸烟、母亲患糖尿病以及机械通气治疗可预测MP和/或LP儿童使用哮喘药物的情况。
MP和LP儿童在7岁前似乎比足月儿对照组更常因哮喘需要药物治疗和住院，但比VP组儿童少见。因特应性皮炎住院随胎龄增加而更常见。
• MP和LP婴儿早期呼吸道疾病及哮喘风险增加。• 关于该患者群体中特应性皮炎的发生情况了解较少。新发现：• 学龄期MP和LP儿童因哮喘的药物治疗和住院情况比足月儿更频繁。男性、母亲吸烟、母亲患糖尿病以及机械通气治疗可预测哮喘。• 因特应性皮炎住院随胎龄增加而更常见。
