Department of Global Public Health and Primary Care, University of Bergen, Bergen, Norway; Department of Pediatrics, Haukeland University Hospital, Bergen, Norway.
Pediatr Allergy Immunol. 2013 Dec;24(8):782-7. doi: 10.1111/pai.12170. Epub 2013 Dec 2.
Asthma and atopic dermatitis are both regarded as atopic diseases. Being born too early is associated with increased risk of asthma, but some studies have indicated that the opposite might be true for atopic dermatitis. We explored in more detail the associations between preterm birth, asthma, and atopic dermatitis.
We analyzed data from Norwegian registries with prospectively collected data. All live births in Norway from 1967 through 2001 were followed through 2005 by linking the Medical Birth Registry of Norway to the National Insurance Scheme and to Statistics Norway. Only severe asthma and atopic dermatitis were registered in the National Insurance Scheme.
Of a total of 1,760,821 children, we identified 9,349 cases (0.5%) with severe asthma and 6,930 cases (0.4%) with severe atopic dermatitis. Compared with children born at term (37-41 wk gestation), preterm birth was associated with increased odds for severe asthma (odds ratio (OR) 1.7 (95% confidence interval (CI): 1.6-1.8) for 32-36 wk gestation and OR 3.6 (95% CI: 3.1-4.2) for 23-31 wk) and decreased odds for severe atopic dermatitis (OR 0.9 (95% CI: 0.8-1.0) for 32-36 wk gestation and OR 0.7 (95% CI: 0.5-1.0) for 23-31 wk). Adjustment for perinatal and socio-demographic factors weakened the association between gestational age and severe asthma, while slightly strengthening the association between gestational age and severe atopic dermatitis.
Preterm birth was associated with increased risk of severe asthma and decreased risk of severe atopic dermatitis.
哮喘和特应性皮炎都被认为是特应性疾病。早产与哮喘风险增加有关，但一些研究表明，特应性皮炎可能恰恰相反。我们更详细地探讨了早产、哮喘和特应性皮炎之间的关联。
我们分析了挪威注册处前瞻性收集数据的结果。通过将挪威医学出生登记处与国家保险计划和挪威统计局相联系，对 1967 年至 2001 年期间所有在挪威出生的活产儿进行了随访，直至 2005 年。仅在国家保险计划中登记严重哮喘和特应性皮炎。
在总共 1760821 名儿童中，我们确定了 9349 例（0.5%）严重哮喘病例和 6930 例（0.4%）严重特应性皮炎病例。与足月产（37-41 周妊娠）相比，早产与严重哮喘的发病风险增加相关（32-36 周妊娠的比值比（OR）为 1.7（95%置信区间（CI）：1.6-1.8），23-31 周妊娠的 OR 为 3.6（95% CI：3.1-4.2）），严重特应性皮炎的发病风险降低（32-36 周妊娠的 OR 为 0.9（95% CI：0.8-1.0），23-31 周妊娠的 OR 为 0.7（95% CI：0.5-1.0））。调整围产期和社会人口学因素后，妊娠年龄与严重哮喘之间的关联减弱，而与严重特应性皮炎之间的关联略有增强。
早产与严重哮喘的风险增加和严重特应性皮炎的风险降低有关。
