Boldt Felix, Liu Weina, Wu Yuzhou, Weil Tanja
Department of Organic Chemistry III/Macromolecular Chemistry, Ulm University, Albert-Einstein- Allee 11, 89081 Ulm, Germany.
Curr Pharm Des. 2016;22(19):2866-72. doi: 10.2174/1381612822666160217141410.
Cells as the smallest unit of life rely on precise macromolecules and programmable supramolecular interactions to accomplish the various vital functions. To translate such strategies to precisely control architectures and interactions into the synthetic world represents an exciting endeavor. Polymers with distinct structures, sequences and architectures are still challenging to achieve. However, in particular for biomedical applications, reproducible synthesis, narrow dispersities, tunable functionalities and additionally biocompatibility of the polymeric materials are crucial. Polymers derived from protein precursors provide many advantages of proteins such as precise monomer sequences and contour lengths, biodegradability and multiple functionalities, which can be synergistically combined with the valuable features of synthetic polymers e.g. stability, tunable solubility and molecular weights. The resulting polymeric biohybrid materials offer many applications ranging from drug delivery to biosensing and therapeutic hydrogels. This minireview summarizes the most recent advances in this field.
细胞作为生命的最小单位，依靠精确的大分子和可编程的超分子相互作用来完成各种重要功能。将这种精确控制结构和相互作用的策略转化到合成领域是一项令人兴奋的工作。具有独特结构、序列和架构的聚合物的合成仍然具有挑战性。然而，特别是对于生物医学应用而言，聚合物材料的可重复合成、窄分散性、可调节的功能以及生物相容性至关重要。源自蛋白质前体的聚合物具有蛋白质的许多优点，如精确的单体序列和轮廓长度、生物可降解性和多种功能，这些优点可以与合成聚合物的宝贵特性（如稳定性、可调节的溶解度和分子量）协同结合。由此产生的聚合物生物杂交材料具有许多应用，从药物递送、生物传感到治疗性水凝胶。本综述总结了该领域的最新进展。
