• 文献检索
  • 文档翻译
  • 深度研究
  • 学术资讯
  • Suppr Zotero 插件Zotero 插件
  • 邀请有礼
  • 套餐&价格
  • 历史记录
应用&插件
Suppr Zotero 插件Zotero 插件浏览器插件Mac 客户端Windows 客户端微信小程序
定价
高级版会员购买积分包购买API积分包
服务
文献检索文档翻译深度研究API 文档MCP 服务
关于我们
关于 Suppr公司介绍联系我们用户协议隐私条款
关注我们

Suppr 超能文献

核心技术专利:CN118964589B侵权必究
粤ICP备2023148730 号-1Suppr @ 2026

文献检索

告别复杂PubMed语法,用中文像聊天一样搜索,搜遍4000万医学文献。AI智能推荐,让科研检索更轻松。

立即免费搜索

文件翻译

保留排版,准确专业,支持PDF/Word/PPT等文件格式,支持 12+语言互译。

免费翻译文档

深度研究

AI帮你快速写综述,25分钟生成高质量综述,智能提取关键信息,辅助科研写作。

立即免费体验

扩张-收缩微通道中的液滴破碎

Droplet Breakup in Expansion-contraction Microchannels.

作者信息

Zhu Pingan, Kong Tiantian, Lei Leyan, Tian Xiaowei, Kang Zhanxiao, Wang Liqiu

机构信息

Department of Mechanical Engineering, the University of Hong Kong, Hong Kong.

HKU-Zhejiang Institute of Research and Innovation (HKU-ZIRI), 311300, Hangzhou, Zhejiang, China.

出版信息

Sci Rep. 2016 Feb 22;6:21527. doi: 10.1038/srep21527.

DOI:10.1038/srep21527
PMID:26899018
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC4761913/
Abstract

We investigate the influences of expansion-contraction microchannels on droplet breakup in capillary microfluidic devices. With variations in channel dimension, local shear stresses at the injection nozzle and focusing orifice vary, significantly impacting flow behavior including droplet breakup locations and breakup modes. We observe transition of droplet breakup location from focusing orifice to injection nozzle, and three distinct types of recently-reported tip-multi-breaking modes. By balancing local shear stresses and interfacial tension effects, we determine the critical condition for breakup location transition, and characterize the tip-multi-breaking mode quantitatively. In addition, we identify the mechanism responsible for the periodic oscillation of inner fluid tip in tip-multi-breaking mode. Our results offer fundamental understanding of two-phase flow behaviors in expansion-contraction microstructures, and would benefit droplet generation, manipulation and design of microfluidic devices.

摘要

我们研究了扩张-收缩微通道对毛细管微流控装置中液滴破碎的影响。随着通道尺寸的变化,注射喷嘴和聚焦孔处的局部剪切应力会发生变化,这对包括液滴破碎位置和破碎模式在内的流动行为有显著影响。我们观察到液滴破碎位置从聚焦孔向注射喷嘴的转变,以及最近报道的三种不同类型的尖端多次破碎模式。通过平衡局部剪切应力和界面张力效应,我们确定了破碎位置转变的临界条件,并对尖端多次破碎模式进行了定量表征。此外,我们还确定了尖端多次破碎模式下内部流体尖端周期性振荡的机制。我们的结果为扩张-收缩微结构中的两相流行为提供了基本认识,并将有助于微流控装置的液滴生成、操控和设计。

相似文献

1
Droplet Breakup in Expansion-contraction Microchannels.扩张-收缩微通道中的液滴破碎
Sci Rep. 2016 Feb 22;6:21527. doi: 10.1038/srep21527.
2
Tip-multi-breaking in Capillary Microfluidic Devices.毛细管微流控装置中的尖端多重断裂
Sci Rep. 2015 Jun 16;5:11102. doi: 10.1038/srep11102.
3
Characterization of acoustic droplet formation in a microfluidic flow-focusing device.微流控流动聚焦装置中声滴形成的表征
Phys Rev E Stat Nonlin Soft Matter Phys. 2011 Dec;84(6 Pt 2):066310. doi: 10.1103/PhysRevE.84.066310. Epub 2011 Dec 12.
4
Prediction of Microdroplet Breakup Regime in Asymmetric T-Junction Microchannels.不对称T型结微通道中微滴破碎模式的预测
Biomed Microdevices. 2018 Aug 13;20(3):72. doi: 10.1007/s10544-018-0310-8.
5
Control of the breakup process of viscous droplets by an external electric field inside a microfluidic device.微流控装置内外部电场对粘性液滴破碎过程的控制。
Soft Matter. 2015 May 21;11(19):3884-99. doi: 10.1039/c5sm00252d.
6
Influence of triangular obstacles on droplet breakup dynamics in microfluidic systems.三角形障碍物对微流控系统中液滴破碎动力学的影响。
Sci Rep. 2024 Jun 10;14(1):13324. doi: 10.1038/s41598-024-63922-y.
7
Breakup dynamics and dripping-to-jetting transition in a Newtonian/shear-thinning multiphase microsystem.牛顿流体/剪切变稀多相微系统中的破裂动力学及滴状到射流状转变
Lab Chip. 2015 Jan 7;15(1):121-34. doi: 10.1039/c4lc00798k.
8
Droplet breakup mechanisms in premix membrane emulsification and related microfluidic channels.预混膜乳化及相关微流道中液滴的破裂机制。
Adv Colloid Interface Sci. 2021 Apr;290:102393. doi: 10.1016/j.cis.2021.102393. Epub 2021 Mar 2.
9
Mode Transition of Droplet Formation in a Semi-3D Flow-Focusing Microfluidic Droplet System.半三维流动聚焦微流控液滴系统中液滴形成的模式转变
Micromachines (Basel). 2018 Mar 21;9(4):139. doi: 10.3390/mi9040139.
10
An "off-the-shelf" capillary microfluidic device that enables tuning of the droplet breakup regime at constant flow rates.一种“现成的”毛细管微流控装置,可在恒定流速下实现液滴断裂模式的调节。
Lab Chip. 2013 Dec 7;13(23):4507-11. doi: 10.1039/c3lc50804h.

引用本文的文献

1
Identification of Evolutionary Trajectories Associated with Antimicrobial Resistance Using Microfluidics.利用微流控技术鉴定与抗菌药物耐药性相关的进化轨迹。
ACS Infect Dis. 2022 Jan 14;8(1):242-254. doi: 10.1021/acsinfecdis.1c00564. Epub 2021 Dec 28.
2
Efficient Generation of Microdroplets Using Tail Breakup Induced with Multi-Branch Channels.使用多分支通道诱导尾部断裂实现微液滴的高效生成。
Molecules. 2021 Jun 17;26(12):3707. doi: 10.3390/molecules26123707.
3
The role of microfluidics in protein formulations with pre-programmed functional characteristics.微流控技术在具有预编程功能特性的蛋白质制剂中的作用。
Biologics. 2018 Dec 3;12:191-197. doi: 10.2147/BTT.S126725. eCollection 2018.
4
Large-scale water collection of bioinspired cavity-microfibers.生物启发的腔状微纤维的大规模集水
Nat Commun. 2017 Oct 20;8(1):1080. doi: 10.1038/s41467-017-01157-4.
5
Well-defined porous membranes for robust omniphobic surfaces via microfluidic emulsion templating.通过微流乳液模板法制备具有明确孔结构的耐用超疏水表面
Nat Commun. 2017 Jun 12;8:15823. doi: 10.1038/ncomms15823.
6
Pinch-off of microfluidic droplets with oscillatory velocity of inner phase flow.通过内相流的振荡速度实现微流体液滴的夹断
Sci Rep. 2016 Aug 11;6:31436. doi: 10.1038/srep31436.

本文引用的文献

1
Microfluidic-based fabrication, characterization and magnetic functionalization of microparticles with novel internal anisotropic structure.基于微流控技术的具有新型内部各向异性结构的微粒的制造、表征及磁功能化
Sci Rep. 2015 Aug 13;5:13060. doi: 10.1038/srep13060.
2
Tip-multi-breaking in Capillary Microfluidic Devices.毛细管微流控装置中的尖端多重断裂
Sci Rep. 2015 Jun 16;5:11102. doi: 10.1038/srep11102.
3
A multi-functional bubble-based microfluidic system.一种基于气泡的多功能微流体系统。
Sci Rep. 2015 Apr 23;5:9942. doi: 10.1038/srep09942.
4
Image decoding of photonic crystal beads array in the microfluidic chip for multiplex assays.用于多重检测的微流控芯片中光子晶体珠阵列的图像解码
Sci Rep. 2014 Oct 24;4:6755. doi: 10.1038/srep06755.
5
Microfluidic conceived pH sensitive core-shell particles for dual drug delivery.用于双重药物递送的微流控设计的 pH 敏感核壳粒子。
Int J Pharm. 2015 Jan 15;478(1):78-87. doi: 10.1016/j.ijpharm.2014.10.010. Epub 2014 Oct 11.
6
Capillary micromechanics for core-shell particles.核壳颗粒的毛细管微力学
Soft Matter. 2014 May 14;10(18):3271-6. doi: 10.1039/c3sm53066c. Epub 2014 Mar 13.
7
Rapid formation of multicellular spheroids in double-emulsion droplets with controllable microenvironment.在具有可控微环境的双乳液滴中快速形成多细胞球体。
Sci Rep. 2013 Dec 10;3:3462. doi: 10.1038/srep03462.
8
Functional polymeric microparticles engineered from controllable microfluidic emulsions.可控微流控乳液工程化的功能性聚合物微球。
Acc Chem Res. 2014 Feb 18;47(2):373-84. doi: 10.1021/ar4001263. Epub 2013 Nov 7.
9
Droplet microfluidics for producing functional microparticles.液滴微流控技术用于制备功能性微颗粒。
Langmuir. 2014 Feb 18;30(6):1473-88. doi: 10.1021/la403220p. Epub 2013 Nov 8.
10
An "off-the-shelf" capillary microfluidic device that enables tuning of the droplet breakup regime at constant flow rates.一种“现成的”毛细管微流控装置,可在恒定流速下实现液滴断裂模式的调节。
Lab Chip. 2013 Dec 7;13(23):4507-11. doi: 10.1039/c3lc50804h.