Ježková Jana, Marek Josef
Third Department of Medicine, First Medical Faculty, Charles University, Prague 2, Czech Republic -
Minerva Endocrinol. 2016 Sep;41(3):366-76. Epub 2016 Feb 19.
Pituitary adenomas are frequently occurring intracranial neoplasms. The aim of the treatment of pituitary adenomas is to normalize hormonal hypersecretion, to preserve the normal pituitary function, to reserve or treat impaired pituitary function and to control tumor growth and its mechanical effects on the surrounding structures. Treatment modalities include surgical, medical and radiation therapy. Radiosurgery is mainly used as a secondary line treatment after surgery for residual or recurrent tumors. The antiproliferative effect is achieved by LKG irradiation in more than 90% of patients. Regarding the functioning pituitary adenomas, the manifestation of the treatment effect is slow and depends mainly on the type of adenoma. Gamma knife irradiation is safe when the maximal doses to pituitary and infundibulum are respected.
垂体腺瘤是常见的颅内肿瘤。垂体腺瘤的治疗目的是使激素分泌过多恢复正常，保留正常垂体功能，保留或治疗受损的垂体功能，以及控制肿瘤生长及其对周围结构的机械影响。治疗方式包括手术、药物和放射治疗。立体定向放射外科主要用作手术后对残留或复发性肿瘤的二线治疗。超过90%的患者通过LKG照射可实现抗增殖效果。对于功能性垂体腺瘤，治疗效果的表现较为缓慢，且主要取决于腺瘤的类型。当尊重垂体和漏斗部的最大剂量时，伽玛刀照射是安全的。
