Mammarella Nicola, Fairfield Beth, Di Domenico Alberto, D'Onofrio Laura, Stuppia Liborio, Gatta Valentina
Department of Psychological Sciences, Health and Territory, University of Chieti, Italy.
Department of Psychological Sciences, Health and Territory, University of Chieti, Italy.
Neurobiol Learn Mem. 2016 Apr;130:129-34. doi: 10.1016/j.nlm.2016.02.009. Epub 2016 Feb 17.
Previous studies found that the ADRA2B gene modulates early perception and attention. Here, we aimed to examine whether ADRA2B polymorphisms also influence emotional working memory and the willingness to implement behaviors (switching affective intonation) in order to avoid negative information, both considered indexes of cognitive-affective flexibility. We examined genotype data collected from 212 healthy females, 91 ADRA2B carriers and 121 non-carriers, and found that carriers showed a positivity bias in working memory. That is, carriers remembered a higher number of positive words compared to negative and neutral words. In addition, although carriers were more unwilling to switch intonation in order to avoid negative information, they showed better recognition memory for words read with a positive intonation. These findings suggest that deletion variants of ADRA2B may show greater levels of cognitive-affective flexibility compared to non-carriers.
先前的研究发现，ADRA2B基因调节早期感知和注意力。在此，我们旨在研究ADRA2B基因多态性是否也会影响情绪工作记忆以及为避免负面信息而实施行为（转换情感语调）的意愿，这两者均被视为认知-情感灵活性的指标。我们检查了从212名健康女性收集的基因型数据，其中91名是ADRA2B基因携带者，121名是非携带者，发现携带者在工作记忆中表现出积极偏向。也就是说，与负面和中性词相比，携带者记住的积极词数量更多。此外，尽管携带者更不愿意为避免负面信息而转换语调，但他们对用积极语调读出的单词表现出更好的识别记忆。这些发现表明，与非携带者相比，ADRA2B基因的缺失变体可能表现出更高水平的认知-情感灵活性。
