Liu Yu-Bin, Zhao Li, Ding Jing, Zhu Jie, Xie Cheng-Long, Wu Zhen-Kai, Yang Xuan, Li Hai
a Departments of Pediatric Orthopedics .
b Neurology, Xin-Hua Hospital , Shanghai Jiao Tong University School of Medicine , Shanghai , China.
Acta Orthop. 2016 Jun;87(3):291-5. doi: 10.3109/17453674.2016.1153359. Epub 2016 Feb 22.
Background and purpose - Results from case-control studies of maternal age at conception and risk of idiopathic clubfoot have been inconsistent. We conducted a meta-analysis to determine whether there is any association between maternal age at conception and the morbidity of idiopathic clubfoot. Methods - We searched PubMed-MEDLINE, EMBASE, and the Cochrane Library up to June 2015 and supplemented the search with manual searches of the reference lists of the articles identified. 11 studies published between 1990 and 2015 were pooled. We investigated heterogeneity in maternal age and whether publication bias might have affected the results. Results - Compared to a control group, maternal age at conception of between 20 and 24 years old was associated with an increased risk of occurrence of clubfoot (OR = 1.2, 95% CI: 1.1-1.4). No such association was found for the age groups of ≥ 35, 30-34, 25-29, and < 20 years. There was no heterogeneity in the age groups of ≥ 35, 30-34, and 20-24 years, moderate heterogeneity in the 25- to 29-year age group, and a large degree of heterogeneity in the group that was < 20 years of age. The prediction intervals for the age groups of 25-29 and < 20 years were 0.56 to 1.3 and -0.39 to 2.4, respectively. We found no evidence of significant publication bias. Interpretation - From the results of this meta-analysis of 11 studies, maternal age at conception between 20 to 24 years of age appears to be associated with an increased risk of occurrence of clubfoot.
背景与目的——关于受孕时母亲年龄与特发性马蹄内翻足风险的病例对照研究结果并不一致。我们进行了一项荟萃分析，以确定受孕时母亲年龄与特发性马蹄内翻足发病率之间是否存在关联。方法——我们检索了截至2015年6月的PubMed-MEDLINE、EMBASE和Cochrane图书馆，并通过手动检索所识别文章的参考文献列表来补充搜索。汇总了1990年至2015年间发表的11项研究。我们调查了母亲年龄的异质性以及发表偏倚是否可能影响结果。结果——与对照组相比，受孕时母亲年龄在20至24岁之间与马蹄内翻足发生风险增加相关（OR = 1.2，95%CI：1.1 - 1.4）。在≥35岁、30 - 34岁、25 - 29岁和<20岁的年龄组中未发现此类关联。≥35岁、30 - 34岁和20 - 24岁年龄组不存在异质性，25至29岁年龄组存在中度异质性，<20岁年龄组存在较大程度的异质性。25 - 29岁和<20岁年龄组的预测区间分别为0.56至1.3和 - 0.39至2.4。我们没有发现显著发表偏倚的证据。解读——从这11项研究的荟萃分析结果来看，受孕时母亲年龄在20至24岁之间似乎与马蹄内翻足发生风险增加相关。
