Razaz Neda, Tremlett Helen, Marrie Ruth Ann, Joseph K S
School of Population and Public Health and Department of Obstetrics & Gynaecology, Faculty of Medicine, University of British Columbia, Vancouver, BC, Canada
Centre for Brain Health and Division of Neurology, Department of Medicine, Faculty of Medicine, University of British Columbia, Vancouver, BC, Canada/Vancouver Coastal Health Research Institute, Vancouver, BC, Canada.
Mult Scler. 2016 Dec;22(14):1830-1840. doi: 10.1177/1352458516631037. Epub 2016 Feb 22.
Although many individuals with multiple sclerosis (MS) experience depression, there are no studies on the frequency and effect of peripartum depression among parents with MS.
To examine the frequency of peripartum depression in individuals with MS and its potential association with children's psychiatric disorders.
We conducted a cohort study in British Columbia, Canada, using linked health databases, of parents with MS and their children, and age-matched unaffected parent-child dyads. The diagnosis of peripartum depression, MS and psychiatric disorders in children was based on information from hospital admission, physician visit and drug prescription claims.
Peripartum depression was significantly more common among MS parents (n = 360) versus unaffected (n = 1207) parents (25.8% vs 18.5%, p value 0.02), especially among MS affected fathers versus unaffected fathers (25.7% vs 10.2%, p value < 0.001). The incidence of psychiatric disorders in children was 3.3 and 2.7 per 100 child-years among children with and without an MS parent, respectively. The rate of psychiatric disorders was significantly higher in children with an MS parent (vs without, hazard ratio (HR): 1.34; 95% confidence interval (CI): 1.03-1.74) and among children with parents who had peripartum depression (HR: 1.87; 95% CI: 1.36-2.55).
Parental MS is associated with a higher risk of peripartum depression and increases the risk of psychiatric disorders in children.
尽管许多多发性硬化症（MS）患者会经历抑郁，但尚无关于患有MS的父母围产期抑郁的发生率及影响的研究。
研究MS患者围产期抑郁的发生率及其与儿童精神疾病的潜在关联。
我们在加拿大不列颠哥伦比亚省利用关联的健康数据库，对患有MS的父母及其子女，以及年龄匹配的未患病父母-子女二元组进行了一项队列研究。围产期抑郁、MS及儿童精神疾病的诊断基于医院入院、医生诊疗及药物处方申请的信息。
与未患病父母（n = 1207）相比，围产期抑郁在患有MS的父母（n = 360）中更为常见（25.8% 对18.5%，p值0.02），尤其是患有MS的父亲与未患病的父亲相比（25.7% 对10.2%，p值<0.001）。有MS父母的儿童和无MS父母的儿童中，精神疾病的发病率分别为每100儿童年3.3例和2.7例。有MS父母的儿童（与无MS父母的儿童相比，风险比（HR）：1.34；95%置信区间（CI）：1.03 - 1.74）以及父母患有围产期抑郁的儿童（HR：1.87；95% CI：1.36 - 2.55）中，精神疾病的发生率显著更高。
父母患有MS与围产期抑郁的较高风险相关，并增加了儿童患精神疾病的风险。
