Haker Michel, Peper Julia, Haagen Miriam, Heesen Christoph, Rahn Anne Christin
Institute of Neuroimmunology and Multiple Sclerosis (MH, JP, CH, ACR), University Medical Center Hamburg-Eppendorf, Hamburg, Germany.
private practice, Hamburg, Germany (MH).
Int J MS Care. 2023 Mar-Apr;25(2):63-70. doi: 10.7224/1537-2073.2021-075. Epub 2022 Oct 13.
Multiple sclerosis (MS) is a common debilitating neurologic disease that affects mostly young women. This review provides an overview of research on the psychosocial impact of parental MS on children to inform clinicians and support people with MS considering parenthood.
A systematic review of the literature was performed by searching the MEDLINE, PsycINFO, and PSYNDEX databases. We included quantitative and mixed-method studies assessing psychosocial outcomes of children with a parent with MS. Studies were screened for eligibility and evaluated for risk of bias.
We screened 608 references, assessed 72 studies in full-text, and included 28 studies in this review. Most of the studies reported on psychosocial adjustment processes, with most results suggesting negative consequences, including difficulties with mood, behavior, or social interaction. Several studies also described associations between children with a parent with MS and increased incidences of psychiatric disorders. Nevertheless, some studies claimed that children with a parent with MS were not more likely to have psychosocial problems compared with children without a parent with MS. A few studies indicated probable positive effects of parental MS, eg potentially increased social competence. Other investigated outcomes were children's coping skills, early childhood development, body image, and effects on education, and these were unaffected or only slightly affected by having a parent with MS.
Having a parent with MS has a relevant effect on children. However, the heterogeneous nature and varying quality of the included studies limit the interpretability of these findings. Further research is needed to provide robust evidence.
多发性硬化症（MS）是一种常见的使人衰弱的神经系统疾病，主要影响年轻女性。本综述概述了关于父母患多发性硬化症对子女心理社会影响的研究，以为临床医生提供信息，并为考虑生育的多发性硬化症患者提供支持。
通过检索MEDLINE、PsycINFO和PSYNDEX数据库对文献进行系统综述。我们纳入了评估父母患有多发性硬化症的儿童心理社会结局的定量和混合方法研究。对研究进行资格筛选并评估偏倚风险。
我们筛选了608篇参考文献，全文评估了72项研究，本综述纳入了28项研究。大多数研究报告了心理社会适应过程，大多数结果表明存在负面后果，包括情绪、行为或社交互动方面的困难。几项研究还描述了父母患有多发性硬化症的儿童与精神疾病发病率增加之间的关联。然而，一些研究称，与父母未患多发性硬化症的儿童相比，父母患有多发性硬化症的儿童不太可能出现心理社会问题。一些研究表明父母患多发性硬化症可能有积极影响，例如可能提高社交能力。其他调查的结果是儿童的应对技能、幼儿发育、身体形象以及对教育的影响，这些受父母患多发性硬化症的影响不大或仅略有影响。
父母患有多发性硬化症对子女有显著影响。然而，纳入研究的异质性和质量参差不齐限制了这些发现的可解释性。需要进一步研究以提供有力证据。
