Eyre Harris A, Air Tracy, Pradhan Alyssa, Johnston James, Lavretsky Helen, Stuart Michael J, Baune Bernhard T
Discipline of Psychiatry, School of Medicine, University of Adelaide, Adelaide, Australia; Semel Institute for Neuroscience and Human Behavior, UCLA, Los Angeles, CA, USA; School of Medicine and Dentistry, James Cook University, Townsville, Australia.
Discipline of Psychiatry, School of Medicine, University of Adelaide, Adelaide, Australia.
Prog Neuropsychopharmacol Biol Psychiatry. 2016 Jul 4;68:1-8. doi: 10.1016/j.pnpbp.2016.02.006. Epub 2016 Feb 20.
Chemokines are increasingly recognised as playing a role in depression. Here we meta-analyse the data on concentrations of all chemokines in patients diagnosed with a major depression versus healthy controls. We included studies which utilised Diagnostic and Statistical Manual (DSM)-IV diagnostic criteria for major depression, participants free from major medical conditions, studies with healthy controls, and unstimulated measurements of chemokines. We only included chemokines which had ≥3 studies performed. Two chemokines and 15 studies in total met criteria for this meta-analysis; 8 for Monocyte Chemotactic Protein (MCP)-1/CCL2 (n=747), and 7 for Interleukin (IL)-8/CXCL8 (n=560). There were significantly higher concentrations of CCL2/MCP-1 in depressed subjects compared with control subjects - overall mean difference of 36.43pg/mL (95% CI: 2.43 to 70.42). There was significant heterogeneity across these studies (I2=98.5%). The estimates of mean difference between the control and depression groups did not remain significant when the trim-and-fill procedure was used to correct for publication bias. There was no significant difference in concentrations of IL-8/CXCL8 in depressed subjects compared with control subjects. Significant heterogeneity was found across these studies (I2=96.7%). The estimates of mean difference between the control and depression groups remained non-significant when the trim-and-fill procedure was used to correct for publication bias. This meta-analysis reports significantly heterogeneity in this field among studies. There are higher concentrations of the chemokine MCP-1/CCL2 in depressed subjects compared with control subjects, and no differences for IL-8/CXCL8. More high quality research and consistent methodologies are needed in this important area of enquiry.
趋化因子在抑郁症中的作用日益受到认可。在此，我们对被诊断为重度抑郁症的患者与健康对照者体内所有趋化因子浓度的数据进行荟萃分析。我们纳入了采用《精神疾病诊断与统计手册》（DSM）-IV重度抑郁症诊断标准的研究、无重大疾病的参与者、有健康对照的研究以及趋化因子的未刺激测量研究。我们仅纳入了有≥3项相关研究的趋化因子。共有两种趋化因子及15项研究符合该荟萃分析的标准；其中关于单核细胞趋化蛋白（MCP）-1/CCL2的研究有8项（n = 747），关于白细胞介素（IL）-8/CXCL8的研究有7项（n = 560）。与对照受试者相比，抑郁症患者体内CCL2/MCP-1的浓度显著更高——总体平均差异为36.43pg/mL（95%置信区间：2.43至70.42）。这些研究存在显著的异质性（I2 = 98.5%）。当采用修剪填充法校正发表偏倚时，对照组与抑郁症组之间平均差异的估计值不再具有显著性。与对照受试者相比，抑郁症患者体内IL-8/CXCL8的浓度无显著差异。这些研究存在显著的异质性（I2 = 96.7%）。当采用修剪填充法校正发表偏倚时，对照组与抑郁症组之间平均差异的估计值仍不具有显著性。该荟萃分析报告了该领域研究之间存在显著的异质性。与对照受试者相比，抑郁症患者体内趋化因子MCP-1/CCL2的浓度更高，而IL-8/CXCL8则无差异。在这个重要的研究领域，需要更多高质量的研究和一致的方法。
