Kildebo S, Breckan R, Nordgaard K, Burhol P G, Jorde R
Medical Department, University Hospital of Tromsø, Norway.
Scand J Gastroenterol. 1989 Dec;24(10):1265-70. doi: 10.3109/00365528909090797.
In a prospective epidemiologic multicentre study in Northern Norway, the incidence of Crohn's disease was 5.8 per 100,000 per year. The highest incidence was found in the county of Nordland, located in the south, and the lowest in Finnmark, located in the north of the region (6.7 and 3.9 per 100,000 per year, respectively). Similarly, there was a lower incidence in rural than in urban areas. Crohn's disease was found as frequently in the large as in the small bowel. The location in the large bowel seemed more often to be associated with extraintestinal manifestations. The male to female ratio was almost 1:1. In males a peak incidence was seen in the age group 20-29 years old, whereas no similar peak was seen in the females. Twenty-two per cent of the cases were diagnosed before the age of 20. In 13.4% of the cases a family history of inflammatory bowel disease was found.
在挪威北部进行的一项前瞻性多中心流行病学研究中,克罗恩病的发病率为每年每10万人中有5.8例。发病率最高的是位于南部的诺尔兰郡,最低的是位于该地区北部的芬马克郡(分别为每年每10万人中有6.7例和3.9例)。同样,农村地区的发病率低于城市地区。在大肠和小肠中克罗恩病的发病频率相当。大肠部位的发病似乎更常与肠外表现相关。男女比例几乎为1:1。男性在20至29岁年龄组发病率最高,而女性则没有类似的高峰。22%的病例在20岁之前被诊断出来。13.4%的病例有炎症性肠病家族史。