Probert C S, Jayanthi V, Pollock D J, Baithun S I, Mayberry J F, Rampton D S
Leicester General Hospital, UK.
Postgrad Med J. 1992 Nov;68(805):914-20. doi: 10.1136/pgmj.68.805.914.
The incidence of Crohn's disease in a defined Bangladeshi community was assessed in a retrospective, epidemiological study in the London Borough of Tower Hamlets from 1972 to 1989. The borough population of 164,000 includes over 28,000 Bangladeshis. Potential cases were identified from hospital pathology and medical records. There were 99 cases of Crohn's disease during the study period, of which five were Bangladeshi. The mean standardized incidence in Bangladeshis was 1.2/10(5)/year in the 1970s and 2.3/10(5)/year in the 1980s compared with 3.8/10(5)/year and 4.1/10(5)/year in Europeans, and 4.6/10(5)/year and 5.4/10(5)/year in West Indians, respectively. None of the changes with time was statistically significant. There were no cases amongst Hindus. The relative risk to Europeans, compared to Bangladeshis, was 2.5 during the 1970s and 2.0 in the 1980s. The difference between European incidence and that of other ethnic groups was not statistically significant; however, the number of Bangladeshi cases was small (five), and diminishes the power of the study. The apparent similarity of the incidences of Crohn's disease in Bangladeshis and Europeans contrasts with findings in other South Asians. Further investigations of the differences in incidence of Crohn's disease in South Asians is needed.
1972年至1989年期间，在伦敦塔哈姆雷区进行了一项回顾性流行病学研究，评估了孟加拉国一个特定社区中克罗恩病的发病率。该行政区有16.4万人口，其中包括2.8万多名孟加拉国人。通过医院病理和医疗记录确定潜在病例。研究期间有99例克罗恩病病例，其中5例为孟加拉国人。20世纪70年代孟加拉国人的平均标准化发病率为1.2/10⁵/年，80年代为2.3/10⁵/年，而欧洲人在这两个时期的发病率分别为3.8/10⁵/年和4.1/10⁵/年，西印度人则分别为4.6/10⁵/年和5.4/10⁵/年。随时间的变化均无统计学意义。印度教徒中无病例。与孟加拉国人相比，欧洲人在20世纪70年代的相对风险为2.5，80年代为2.0。欧洲人的发病率与其他种族群体的发病率之间的差异无统计学意义；然而，孟加拉国病例数较少（5例），削弱了研究的效力。孟加拉国人和欧洲人克罗恩病发病率的明显相似性与其他南亚人的研究结果形成对比。需要进一步调查南亚人克罗恩病发病率的差异。
