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幽门螺杆菌感染与慢性丙型肝炎之间的关联：一项荟萃分析和试验序贯分析

The Association between Helicobacter pylori Infection and Chronic Hepatitis C: A Meta-Analysis and Trial Sequential Analysis.

作者信息

Wang Juan, Li Wen-Ting, Zheng Yi-Xiang, Zhao Shu-Shan, Li Ning, Huang Yan, Zhou Rong-Rong, Huang Ze-Bing, Fan Xue-Gong

机构信息

Department of Infectious Diseases, Xiangya Hospital, Central South University, Changsha 410008, China; Key Laboratory of Viral Hepatitis, Hunan, China.

Department of Orthopedics, Xiangya Hospital, Central South University, Changsha 410008, China.

出版信息

Gastroenterol Res Pract. 2016;2016:8780695. doi: 10.1155/2016/8780695. Epub 2016 Jan 24.

DOI:10.1155/2016/8780695
PMID:26904112
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC4745339/
Abstract

Purpose. Helicobacter pylori is a common gastric disease-inducing pathogen. Although an increasing number of recent studies have shown that H. pylori is a risk factor for liver disease, the potential association between H. pylori infection and chronic hepatitis C still remains controversial. The aim of our meta-analysis was to evaluate a potential association between H. pylori infection and chronic hepatitis C. Methods. We searched the PubMed, Embase, CNKI, Web of Science, and the Cochrane Central Register of Controlled Trials (CENTRAL) databases between January 1, 1994, and May 1, 2015. Results. This study included a total of 1449 patients with chronic hepatitis C and 2377 control cases. The prevalence of H. pylori was significantly higher in patients with chronic hepatitis C than in those without chronic hepatitis C. The pooled odds ratio was 2.93. In a subgroup analysis, the odds ratios were 4.48 for hepatitis C virus- (HCV-) related cirrhosis and 5.45 for hepatocellular carcinoma. Conclusion. Our study found a strong association between H. pylori and chronic hepatitis C, particularly during the HCV progression stage; thus, we recommend active screening for H. pylori in patients with chronic hepatitis C.

摘要

目的。幽门螺杆菌是一种常见的致胃病病原体。尽管最近越来越多的研究表明幽门螺杆菌是肝病的一个危险因素，但幽门螺杆菌感染与慢性丙型肝炎之间的潜在关联仍存在争议。我们进行荟萃分析的目的是评估幽门螺杆菌感染与慢性丙型肝炎之间的潜在关联。方法。我们检索了1994年1月1日至2015年5月1日期间的PubMed、Embase、中国知网、Web of Science以及Cochrane对照试验中心注册库（CENTRAL）数据库。结果。本研究共纳入1449例慢性丙型肝炎患者和2377例对照病例。慢性丙型肝炎患者中幽门螺杆菌的患病率显著高于无慢性丙型肝炎者。合并比值比为2.93。在亚组分析中，丙型肝炎病毒（HCV）相关肝硬化的比值比为4.48，肝细胞癌的比值比为5.45。结论。我们的研究发现幽门螺杆菌与慢性丙型肝炎之间存在密切关联，尤其是在HCV进展阶段；因此，我们建议对慢性丙型肝炎患者进行幽门螺杆菌的主动筛查。

https://cdn.ncbi.nlm.nih.gov/pmc/blobs/4936/4745339/11d43bc116a9/GRP2016-8780695.005.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/4936/4745339/a34002f0525c/GRP2016-8780695.001.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/4936/4745339/7ffe9905db74/GRP2016-8780695.002.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/4936/4745339/ebefd50c2b72/GRP2016-8780695.003.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/4936/4745339/443bfc4f10d1/GRP2016-8780695.004.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/4936/4745339/11d43bc116a9/GRP2016-8780695.005.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/4936/4745339/a34002f0525c/GRP2016-8780695.001.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/4936/4745339/7ffe9905db74/GRP2016-8780695.002.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/4936/4745339/ebefd50c2b72/GRP2016-8780695.003.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/4936/4745339/443bfc4f10d1/GRP2016-8780695.004.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/4936/4745339/11d43bc116a9/GRP2016-8780695.005.jpg

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