Zoology Department, Faculty of Science, Menoufia University, Menoufia, Egypt.
Biomed Pharmacother. 2013 Jun;67(5):367-74. doi: 10.1016/j.biopha.2013.03.004. Epub 2013 Mar 23.
Hepatitis C is an infectious disease affecting the liver. Chronic infection can progress fibrosis and cirrhosis, liver failure or liver cancer. Helicobacter pylori (H. pylori) is a spiral bacterium infects the stomach of more than 50% of the human population worldwide. H. pylori DNA has been identified in human livers and has been implicated in chronic liver disease and liver cancer. The present work was aimed to study the histological and histochemical alterations in liver of HCV patients with or without H. pylori infection. Immunohistochemical detection of H. pylori showed positive reactivity in 62 biopsies out of 100 biopsies (38% HCV patients and 62% HCV patients coinfected with H. pylori). Histological examination of liver of HCV patients showed microvesicular and macrovesicular steatosis, lymphocytic infiltrations, fibrosis and cirrhosis. Cirrhotic nodules and impairment of hepatic parenchyma were common in HCV patients coinfected with H. pylori. HCV patients coinfected with H. pylori recorded higher NIC score and pronounced fibrosis stages than HCV patients. Glycogen and total proteins decreased in hepatocytes and cirrhotic nodules in HCV patients. Such decrease was marked in liver of HCV patients coinfected with H. pylori. So it is recommended to perform a complete analysis for H. pylori in HCV patients suggesting that it will help in therapy of this disease.
丙型肝炎是一种影响肝脏的传染病。慢性感染可导致纤维化和肝硬化、肝功能衰竭或肝癌。幽门螺杆菌（H. pylori）是一种螺旋菌，感染了全球超过 50%的人口的胃部。已经在人类肝脏中鉴定出 H. pylori 的 DNA，并与慢性肝病和肝癌有关。本研究旨在研究丙型肝炎患者合并或不合并 H. pylori 感染时肝脏的组织学和组织化学改变。免疫组织化学检测显示，在 100 个活检样本中的 62 个活检样本中（38%的丙型肝炎患者和 62%的丙型肝炎患者合并 H. pylori 感染）显示出阳性反应。丙型肝炎患者的肝脏组织学检查显示出微泡性和大泡性脂肪变性、淋巴细胞浸润、纤维化和肝硬化。丙型肝炎患者合并 H. pylori 感染时，肝硬化结节和肝实质损伤更为常见。丙型肝炎患者合并 H. pylori 感染时，NIC 评分和纤维化阶段较高。丙型肝炎患者的肝细胞和肝硬化结节中的糖原和总蛋白减少。丙型肝炎患者合并 H. pylori 感染时，这种减少更为明显。因此，建议对丙型肝炎患者进行 H. pylori 的全面分析，这有助于治疗这种疾病。
