Fabiani Claudia, Li Voti Roberto, Rusciano Dario, Mutolo Maria Giulia, Pescosolido Nicola
Department of Ophthalmology, Humanitas Research Hospital, Via Alessandro Manzoni 56, Rozzano, 20089 Milan, Italy.
SBAI Department, Sapienza University of Rome, Via A. Scarpa 16, 00161 Rome, Italy.
J Ophthalmol. 2016;2016:3076031. doi: 10.1155/2016/3076031. Epub 2016 Jan 20.
Purpose. To study the geographical distribution of corneal temperature (CT) and its influence on the intraocular pressure (IOP) of healthy human volunteers. Materials and Methods. Fifteen subjects (7 M, 8 F), 33.8 ± 17.4 years old, were enrolled in this pilot, cross-sectional study. Measurements of CT were taken after one hour with closed eyelids (CET) or closed eyelids with a cooling mask (cm-CET) and compared to baseline. Results. If compared to baseline, after CET, average CT significantly increased by 0.56°C in the RE and by 0.48°C in the LE (p < 0.001) and IOP concomitantly significantly increased by 1.13 mmHg and 1.46 mmHg, respectively, in each eye (p < 0.001). After cm-CET, average CT significantly decreased by 0.11°C and 0.20°C, respectively, in the RE and LE (RE p = 0.04; LE p = 0.024), followed by a significant IOP decrease of 2.19 mmHg and 1.54 mmHg, respectively, in each eye (RE p < 0.001; LE p = 0.0019). Conclusion. Significant variations of CT occurred after CET and cm-CET and were directly correlated with significant differences of IOP. It can be speculated that both oxidative stress and sympathetic nerve fiber stimulation by temperature oscillations may affect the regulation of AH vortex flow and turnover, thus influencing IOP values.
目的。研究健康人类志愿者角膜温度（CT）的地理分布及其对眼压（IOP）的影响。材料与方法。15名受试者（7名男性，8名女性），年龄33.8±17.4岁，参与了这项试点横断面研究。在闭眼1小时后（CET）或使用冷却面罩闭眼后（cm - CET）测量CT，并与基线进行比较。结果。与基线相比，CET后，右眼平均CT显著升高0.56°C，左眼平均CT显著升高0.48°C（p < 0.001），且每只眼睛的IOP分别随之显著升高1.13 mmHg和1.46 mmHg（p < 0.001）。cm - CET后，右眼和左眼的平均CT分别显著降低0.11°C和0.20°C（右眼p = 0.04；左眼p = 0.024），随后每只眼睛的IOP分别显著降低2.19 mmHg和1.54 mmHg（右眼p < 0.001；左眼p = 0.0019）。结论。CET和cm - CET后CT发生显著变化，且与IOP的显著差异直接相关。可以推测，氧化应激和温度振荡对交感神经纤维的刺激可能都会影响房水涡动流和周转的调节，从而影响IOP值。
