Guo Shiqi, Wu Kaijin, Li Chengpan, Wang Hao, Sun Zheng, Xi Dawei, Zhang Sheng, Ding Weiping, Zaghloul Mona E, Wang Changning, Castro Fernando A, Yang Dong, Zhao Yunlong
John A. Paulson School of Engineering and Applied Sciences, Harvard University, Cambridge, MA 02138, USA.
CAS Key Laboratory of Mechanical Behavior and Design of Materials, Department of Modern Mechanics, CAS Center for Excellence in Complex System Mechanics, University of Science and Technology of China, Hefei, Anhui 230026, China.
Matter. 2021 Mar 3;4(3):969-985. doi: 10.1016/j.matt.2020.12.002. Epub 2020 Dec 30.
Smart contact lenses attract extensive interests due to their capability of directly monitoring physiological and ambient information. However, previous demonstrations usually lacked efficient sensor modalities, facile fabrication process, mechanical stability, or biocompatibility. Here, we demonstrate a flexible approach for fabrication of multifunctional smart contact lenses with an ultrathin MoS transistors-based serpentine mesh sensor system. The integrated sensor systems contain a photodetector for receiving optical information, a glucose sensor for monitoring glucose level directly from tear fluid, and a temperature sensor for diagnosing potential corneal disease. Unlike traditional sensors and circuit chips sandwiched in the lens substrate, this serpentine mesh sensor system can be directly mounted onto the lenses and maintain direct contact with tears, delivering high detection sensitivity, while being mechanically robust and not interfering with either blinking or vision. Furthermore, the cytotoxicity tests reveal good biocompatibility, thus holding promise as next-generation soft electronics for healthcare and medical applications.
智能隐形眼镜因其能够直接监测生理和环境信息而引起了广泛关注。然而，以往的演示通常缺乏高效的传感器模式、简便的制造工艺、机械稳定性或生物相容性。在此，我们展示了一种灵活的方法，用于制造具有基于超薄MoS晶体管的蛇形网状传感器系统的多功能智能隐形眼镜。集成传感器系统包括一个用于接收光学信息的光电探测器、一个用于直接从泪液中监测葡萄糖水平的葡萄糖传感器以及一个用于诊断潜在角膜疾病的温度传感器。与夹在镜片基板中的传统传感器和电路芯片不同，这种蛇形网状传感器系统可以直接安装在镜片上，并与泪液保持直接接触，具有高检测灵敏度，同时机械坚固，不干扰眨眼或视力。此外，细胞毒性测试显示出良好的生物相容性，因此有望成为用于医疗保健和医疗应用的下一代软电子产品。
