Belfast Health and Social Care Trust, Northern Ireland, UK.
Belfast Health and Social Care Trust, Northern Ireland, UK.
Cont Lens Anterior Eye. 2019 Apr;42(2):216-219. doi: 10.1016/j.clae.2018.11.007. Epub 2018 Nov 30.
To explore the relationship between intraocular pressure (IOP) measurements and topographical variations in corneal curvature and corneal thickness in a cohort of keratoconic patients presenting to a newly-established regional Keratoconic diagnostic and monitoring clinic in Northern Ireland.
IOP was recorded, using a hand held ICARE tonometer, at central, nasal and temporal locations on keratoconic corneae of 27 consecutive patients attending clinic. Pachymetry and sagittal keratometry were recorded in matched locations using the Pentacam Topographer. Eyes with history of corneal surgery or anterior surface pathology were excluded.
The median (interquartile range) central keratometry, pachymetry (CCT) and IOP measurements for 49 eyes were 44.1D (42.2D-48.1D); 495 μm (460 μm-526 μm); 10 mmHg (8 mmHg-13 mmHg) respectively. Temporal and nasal keratometry, pachymetry, and IOP values, recorded on midline, were temporal 41.9D (40.7D-42.8D); 621 μm (579 μm-650 μm); 14 mmHg (11 mmHg-16 mmHg); nasal 40.8D (39.5D-42.5D); 641 μm (599 μm-698 μm); 13 mmHg (12 mmHg-17 mmHg). A moderate correlation was shown between reduction in CCT and increase in mean central keratometry (Spearman's Coefficient (ρ) -0.72 P = 0.00). A moderate correlation was found between reduction in CCT and reduction in IOP, as recorded centrally (ρ = 0.37 P = 0.01). Mid-peripheral values demonstrated similar trends in the relationship between keratometry and IOP (nasal ρ = -0.47 P = 0.00; temporal ρ = -0.38 P = 0.00) and pachymetry and IOP (nasal ρ = 0.29 P = 0.05; temporal ρ = 0.33 p = 0.02).
In this pilot study, a positive correlation exists between pachymetry, keratometry and IOP. Topographically variations in intraocular pressure mimic changes in keratometry and pachymetry.
在北爱尔兰新成立的区域性圆锥角膜诊断和监测诊所中，对一组就诊的圆锥角膜患者的眼内压（IOP）测量值与角膜曲率和角膜厚度的地形变化之间的关系进行探讨。
使用 ICARE 眼压计对手边的角膜进行眼压测量，在 27 名连续就诊的患者角膜的中央、鼻侧和颞侧位置进行记录。使用 Pentacam 地形仪在匹配的位置记录角膜厚度和矢状角膜曲率。排除有角膜手术史或前表面病变的眼睛。
49 只眼的中央角膜曲率、角膜厚度（CCT）和 IOP 测量值的中位数（四分位数范围）分别为 44.1D（42.2D-48.1D）；495μm（460μm-526μm）；10mmHg（8mmHg-13mmHg）。记录在中线上的颞侧和鼻侧角膜曲率、角膜厚度和 IOP 值分别为颞侧 41.9D（40.7D-42.8D）；621μm（579μm-650μm）；14mmHg（11mmHg-16mmHg）；鼻侧 40.8D（39.5D-42.5D）；641μm（599μm-698μm）；13mmHg（12mmHg-17mmHg）。中央 CCT 减少与平均中央角膜曲率增加之间呈中度相关性（Spearman 系数（ρ）-0.72，P=0.00）。在中央位置记录到的 CCT 减少与 IOP 减少之间存在中度相关性（ρ=0.37，P=0.01）。中周值显示角膜曲率与眼压（鼻侧ρ=-0.47，P=0.00；颞侧ρ=-0.38，P=0.00）和角膜厚度与眼压（鼻侧ρ=0.29，P=0.05；颞侧ρ=0.33，P=0.02）之间存在类似的关系趋势。
在这项初步研究中，角膜厚度、角膜曲率和眼压之间存在正相关。眼压的地形变化与角膜曲率和角膜厚度的变化相似。
