Halabi Hussein, Mulla Israa
King Faisal Specialist Hospital & Research Center, P.O. Box 40047, Jeddah 21499, Saudi Arabia.
Case Rep Rheumatol. 2016;2016:7367232. doi: 10.1155/2016/7367232. Epub 2016 Jan 20.
We report a case of an 18-year-old girl who presented to our hospital with history of recurrent respiratory infections, amenorrhea, and symmetric polyarthritis. She was diagnosed with rheumatoid arthritis (RA), Kartagener's syndrome (KS), and hyperprolactinemia. There have been very few case reports in the literature of RA occurring in the setting of KS, theoretically proposed to be due to chronic stimulation of the immune system by recurrent infections. Furthermore, hyperprolactinemia has been hypothesized to mirror RA disease activity and case reports of treatment with dopamine agonists have led to the speculation of whether or not they represent a new line of experimental treatment in the future. Our patient was found to have both KS and hyperprolactinemia together in the setting of RA, and based on our literature search, this is the first reported case of such a combination. This strikes a very intriguing question: are these three conditions interlinked by a yet to be defined association? And treatment of which condition leads to the resolution of the other?
我们报告了一例18岁女孩，她因反复呼吸道感染、闭经和对称性多关节炎病史前来我院就诊。她被诊断为类风湿性关节炎（RA）、卡塔格内综合征（KS）和高催乳素血症。文献中关于KS背景下发生RA的病例报告非常少，理论上认为这是由于反复感染对免疫系统的慢性刺激所致。此外，有人推测高催乳素血症反映了RA疾病活动，多巴胺激动剂治疗的病例报告引发了对它们是否代表未来新的实验性治疗方法的猜测。我们的患者在RA背景下同时患有KS和高催乳素血症，根据我们的文献检索，这是首例此类组合的报告病例。这引出了一个非常有趣的问题：这三种情况是否通过一种尚未明确的关联相互联系？治疗其中一种情况是否会导致另一种情况得到缓解？
