热敏灸治疗脊髓损伤后神经源性膀胱的疗效和安全性的系统评价和 Meta 分析方案。
Efficacy and safety of heat-sensitive moxibustion in the treatment of neurogenic bladder after spinal cord injury: A protocol for systematic review and meta-analysis.
机构信息
Henan University of Chinese Medicine.
The First Affiliated Hospital of Henan University of Chinese Medicine, Zhengzhou, Henan, China.
出版信息
Medicine (Baltimore). 2021 Jun 18;100(24):e26424. doi: 10.1097/MD.0000000000026424.
BACKGROUND
Spinal cord injury (SCI) is one of the most disabling and destructive neurological diseases. Neurogenic bladder dysfunction (NBD) is one of the serious complications after SCI, 80% of patients after SCI will have neurogenic bladder symptoms. NBD after SCI may lead to urinary retention, urinary incontinence, and urinary tract infection. In severe cases, it can lead to renal failure or even death. NBD after SCI not only seriously affects the patient's quality of life but also physical and mental health. NBD after SCI is a social and medical problem. In recent years, more and more clinical studies prove that heat-sensitive can improve the clinical symptoms of NBD after SCI. Therefore, this article conducts a systematic evaluation and meta-analysis on the efficacy and safety of heat-sensitive moxibustion in treating NBD after SCI.
METHODS
Search 8 electronic databases including PubMed, Embase, Web of Science, The Cochrane Library, Clinical Trials, China National Knowledge Infrastructure, China Science and Technology Journal Database, Wanfang Database, and China Biomedical Literature Database. We will search above electronic databases from the inception to May 2021, without any language restriction. Clinical randomized controlled trials containing heat-sensitive moxibustion for NBD after SCI and eligible interventions(s) and outcome(s) were included, with no limitation of language and publication status. Two researchers will independently conduct literature search, screening, information extraction, quality assessment, and data analysis. Review Manager 5.3 software will be used for statistical analysis.
RESULTS
The findings will be submitted to a peer-reviewed publication.
CONCLUSION
This systematic review and meta-analysis will provide a standard clinical decision-making guideline for heat-sensitive moxibustion treatment of NBD after SCI.
INPLASY REGISTRATION NUMBER
INPLASY202150071.
背景
脊髓损伤（SCI）是最具破坏性和致残性的神经系统疾病之一。神经源性膀胱功能障碍（NBD）是 SCI 后的严重并发症之一，80%的 SCI 后患者会出现神经源性膀胱症状。SCI 后 NBD 可导致尿潴留、尿失禁和尿路感染。在严重的情况下，它可导致肾衰竭甚至死亡。SCI 后 NBD 不仅严重影响患者的生活质量，还会影响其身心健康。SCI 后 NBD 是一个社会和医学问题。近年来，越来越多的临床研究证明热敏灸可以改善 SCI 后 NBD 的临床症状。因此，本文对热敏灸治疗 SCI 后 NBD 的疗效和安全性进行了系统评价和荟萃分析。
方法
检索 PubMed、Embase、Web of Science、The Cochrane Library、ClinicalTrials、中国知网、中国科技期刊数据库、万方数据库和中国生物医学文献数据库 8 个电子数据库，检索时间从建库至 2021 年 5 月，无语言限制。纳入包含热敏灸治疗 SCI 后 NBD 的临床随机对照试验，以及合格的干预措施和结局，不限制语言和发表状态。两名研究者将独立进行文献检索、筛选、信息提取、质量评估和数据分析。采用 Review Manager 5.3 软件进行统计分析。
结果
研究结果将提交给同行评议的出版物。
结论
本系统评价和荟萃分析将为热敏灸治疗 SCI 后 NBD 提供标准的临床决策指南。
INPLASY 注册号：INPLASY202150071。
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