Chuang T L, Wang Y F, Tsai C H, Chiu J E, Lee M S, Chiou W Y, Lin H Y, Tsai W T, Hung S K
School of Medicine, Tzu Chi University, Hualian; Department of Radiation Oncology, Buddhist Dalin Tzu Chi Hospital, Chiayi, Taiwan.
Indian J Cancer. 2015 Jul-Sep;52(3):398-401. doi: 10.4103/0019-509X.176733.
This study aimed to evaluate the salivary gland function changes by sialoscintigraphy in locally advanced nasopharyngeal cancer (NPC) after intensity modulated radiotherapy (IMRT).
Salivary function was assessed by sialoscintigraphy. Quantitative sialoscintigraphy was performed in 24 NPC patients prior to and after IMRT. Results were categorized in four groups according to the duration of treatment. The sialoscintigraphy parameters were examined.
Sialoscintigraphy showed a significant difference in the secretion of each interval groups. The parameters of scintigraphy, except maximum accumulation (MA) of submandibular glands, decreased first after radiotherapy, and then recovered. However, the MA of submandibular glands was continuously downhill after radiation.
The sialoscintigraphy parameters of each gland changed with the different radiation dose and follow-up intervals. The salivary function was influenced after radiotherapy in locally advanced NPC, especially, in the submandibular gland. Strategies to improve the salivary function should be assessed.
本研究旨在通过唾液腺闪烁扫描术评估局部晚期鼻咽癌（NPC）患者在调强放疗（IMRT）后唾液腺功能的变化。
通过唾液腺闪烁扫描术评估唾液功能。对24例NPC患者在IMRT前后进行定量唾液腺闪烁扫描术。根据治疗持续时间将结果分为四组。检查唾液腺闪烁扫描术参数。
唾液腺闪烁扫描术显示各间隔组的分泌存在显著差异。闪烁扫描术参数中，除颌下腺的最大积聚（MA）外，放疗后先下降，然后恢复。然而，颌下腺的MA在放疗后持续下降。
各腺体的唾液腺闪烁扫描术参数随不同的辐射剂量和随访间隔而变化。局部晚期NPC患者放疗后唾液功能受到影响，尤其是颌下腺。应评估改善唾液功能的策略。
