Department of Radiation Oncology, Fudan University Shanghai Cancer Center, 399 Ling Ling Road, 200032, Shanghai, People's Republic of China.
Int J Clin Oncol. 2013 Oct;18(5):801-7. doi: 10.1007/s10147-012-0464-y. Epub 2012 Aug 15.
We investigated the value of magnetic resonance sialography for evaluating xerostomia induced by intensity-modulated radiotherapy for nasopharyngeal carcinoma.
Fourteen patients with nasopharyngeal carcinoma were treated with intensity-modulated radiotherapy. Salivary function was assessed by magnetic resonance sialography and subjective evaluation criteria pre-treatment, 1 week and 1 year post-radiotherapy. A magnetic resonance sialography categorical scoring system was used to compare the visibility of salivary ducts.
The average mean dose was 38.93 Gy to the parotid glands and 59.34 Gy to the submandibular glands. Before radiotherapy, the visibility scores of both the parotid and submandibular ducts increased after secretion stimulation. The scores decreased and the response to stimulation was attenuated 1 week post-radiotherapy. For most of the parotid ducts, the visibility score improved at 1 year post-radiotherapy both at rest and under stimulation, but not for the submandibular ducts. With a median follow-up of 12.3 months, 8/12 patients had grade 1 xerostomia and 4/12 had grade 2 xerostomia.
Magnetic resonance sialography allows non-invasive evaluation of radiation-induced ductal changes in the major salivary glands and enables reliable prediction of radiation-induced xerostomia.
我们研究了磁共振涎管成像在评价鼻咽癌调强放疗后口干症中的价值。
14 例鼻咽癌患者接受调强放疗。在治疗前、治疗后 1 周和 1 年，通过磁共振涎管成像和主观评价标准评估唾液功能。采用磁共振涎管分类评分系统比较涎管的显影情况。
腮腺和颌下腺的平均平均剂量分别为 38.93 Gy 和 59.34 Gy。放疗前，腮腺和颌下腺导管在分泌刺激后可见度评分增加。放疗后 1 周，评分下降，刺激反应减弱。对于大多数腮腺导管，在休息和刺激下，放疗后 1 年的可见度评分均有所改善，但颌下腺导管则不然。中位随访 12.3 个月时，12 例患者中有 8 例出现 1 级口干，4 例出现 2 级口干。
磁共振涎管成像可无创性评估大涎腺导管的放射性改变，能可靠预测放疗后口干症。
