金黄色葡萄球菌与肺炎链球菌的相互作用及对肺炎球菌疫苗的反应：神话还是现实？
Staphylococcus aureus and Streptococcus pneumoniae interaction and response to pneumococcal vaccination: Myth or reality?
作者信息
Reiss-Mandel Aylana, Regev-Yochay Gili
机构信息
a Epidemiology of Infectious Diseases Section; Gertner Institute ; Tel-Hashomer , Israel.
b Infectious Dis. Unit; Sheba Medical Center; Ramat-Gan; Affiliated to the Sackler School of Medicine; Tel-Aviv University ; Tel Aviv , Israel.
出版信息
Hum Vaccin Immunother. 2016;12(2):351-7. doi: 10.1080/21645515.2015.1081321.
Abstract
S. aureus and S. pneumoniae are both common pathogens that are also carried by a large proportion of healthy individuals in the nasal and nasopharyngeal spaces. A negative association between carriage of S. aureus and S. pneumoniae has been reported in children in various epidemiologic studies from different geographical regions. Most studies found that the negative association between S. pneumoniae and S. aureus was significant only for carriage of vaccine-type S. pneumoniae strains. In this review, we summarize the various suggested mechanisms of this suggested bacterial interference, and the clinical implications reported following PCV introduction to date in various geographical regions.
摘要
金黄色葡萄球菌和肺炎链球菌都是常见病原体，很大比例的健康个体在鼻腔和鼻咽部也携带这些病菌。来自不同地理区域的多项流行病学研究报告称，儿童中金黄色葡萄球菌和肺炎链球菌的携带之间存在负相关。大多数研究发现，肺炎链球菌和金黄色葡萄球菌之间的负相关仅在疫苗型肺炎链球菌菌株的携带方面具有显著性。在本综述中，我们总结了这种推测的细菌干扰的各种可能机制，以及迄今为止在不同地理区域引入肺炎球菌结合疫苗（PCV）后报告的临床意义。
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