Wen Guan, Qu Xiao-Xia, Wang Dan, Chen Xing-Xiu, Tian Xin-Chuan, Gao Feng, Zhou Xian-Li
Department of Chinese Traditional Herbal, Agronomy College, Sichuan Agriculture University, Chengdu 611130, PR China.
Department of Chinese Traditional Herbal, Agronomy College, Sichuan Agriculture University, Chengdu 611130, PR China.
Fitoterapia. 2016 Apr;110:26-37. doi: 10.1016/j.fitote.2016.02.010. Epub 2016 Feb 22.
Taxane-type anticancer drugs, including paclitaxel and its semi-synthetic derivatives docetaxel and cabazitaxel, are widely applied to chemotherapy of malignancy like breast cancer, ovarian cancer, non-small cell lung cancer and prostate cancer. However, their clinical applications are generally limited by scarce natural resources, various side effects and multidrug resistance. Therefore, it is significant to develop paclitaxel-mimics with simplified structure, fewer side effects and improved pharmaceutical properties. Based on our investigation on chemistry of paclitaxel, the current review summarized the most recent advances in the design, synthesis and biological activities of paclitaxel-mimics, which could be appealing to researchers in the field of medicinal chemistry and oncology. Meanwhile, smart design, interesting synthesis and potential bioactivities of these novel compounds may also provide valuable reference for the wider scientific communities.
紫杉烷类抗癌药物，包括紫杉醇及其半合成衍生物多西他赛和卡巴他赛，广泛应用于乳腺癌、卵巢癌、非小细胞肺癌和前列腺癌等恶性肿瘤的化疗。然而，它们的临床应用通常受到自然资源稀缺、各种副作用和多药耐药性的限制。因此，开发结构简化、副作用更少且药学性质改善的紫杉醇类似物具有重要意义。基于我们对紫杉醇化学的研究，本综述总结了紫杉醇类似物在设计、合成和生物活性方面的最新进展，这可能会吸引药物化学和肿瘤学领域的研究人员。同时，这些新型化合物的巧妙设计、有趣的合成方法和潜在的生物活性也可能为更广泛的科学界提供有价值的参考。
