Visovatti Moira A, Reuter-Lorenz Patricia A, Chang Alfred E, Northouse Laurel, Cimprich Bernadine
University of Michigan in Ann Arbor.
Oncol Nurs Forum. 2016 Mar;43(2):169-78. doi: 10.1188/16.ONF.43-02AP.
PURPOSE/OBJECTIVES: To assess cognitive function in individuals with colorectal cancer (CRC) and identify factors associated with cognitive effects.
DESIGN: Cross-sectional, comparative design. .
SETTING: Midwest hospital. .
Men and women with (n = 50) and without (n = 50) CRC.
Comparative and regression analyses were performed to assess the relationship between cognition and CRC.
MAIN RESEARCH VARIABLES: Attention, cognitive control, and memory function were assessed with neuropsychological tests and self-report. .
Compared to healthy volunteers, individuals with CRC performed worse and reported more problems on tasks requiring attention and cognitive control (p < 0.05). After controlling for covariates, poorer performance on tasks of attention and cognitive control was associated (p < 0.001) with having CRC, older age, and less education. In contrast, poorer perceived attention and cognitive control were associated (p < 0.001) with greater fatigue but not CRC.
Individuals with CRC are vulnerable to cognitive problems. In addition, older age, less education, and fatigue can increase risk for worse cognitive performance and self-reported cognition.
Cognitive problems can profoundly affect an individual's ability to function in everyday life and cope with cancer. Nurses should assess for cognitive problems in patients with CRC and intervene to reduce distress.
目的/目标：评估结直肠癌（CRC）患者的认知功能，并确定与认知影响相关的因素。
横断面比较设计。
中西部医院。
患有CRC的男性和女性（n = 50）以及未患CRC的男性和女性（n = 50）。
进行比较分析和回归分析，以评估认知与CRC之间的关系。
通过神经心理学测试和自我报告评估注意力、认知控制和记忆功能。
与健康志愿者相比，CRC患者在需要注意力和认知控制的任务上表现更差，且报告的问题更多（p < 0.05）。在控制协变量后，注意力和认知控制任务表现较差与患有CRC、年龄较大和受教育程度较低相关（p < 0.001）。相比之下，自我感知的注意力和认知控制较差与疲劳程度较高相关（p < 0.001），但与CRC无关。
CRC患者易出现认知问题。此外，年龄较大、受教育程度较低和疲劳会增加认知表现较差和自我报告认知问题的风险。
认知问题会深刻影响个体在日常生活中的功能以及应对癌症的能力。护士应评估CRC患者的认知问题并进行干预以减轻痛苦。
