Park Ki Soo, Lee Chang Yeol, Park Hyun Gyu
Department of Chemical and Biomolecular Engineering (BK 21+ program), KAIST, Daejeon 305-338, Republic of Korea.
Chem Commun (Camb). 2016 Apr 7;52(27):4868-71. doi: 10.1039/c6cc00454g. Epub 2016 Feb 24.
We herein develop a new strategy that modulates DNA polymerase activity in a reversible and switchable manner by using the novel interactions between DNA bases and metal ions (T-Hg(2+)-T and C-Ag(+)-C) inside a DNA aptamer capable of inhibiting DNA polymerase.
我们在此开发了一种新策略，该策略通过利用能够抑制DNA聚合酶的DNA适配体内部DNA碱基与金属离子（T-Hg(2+)-T和C-Ag(+)-C）之间的新型相互作用，以可逆和可切换的方式调节DNA聚合酶活性。
