Notelovitz M
Women's Medical and Diagnostic Center, Climacteric Clinic Inc., Gainesville, FL 32607.
Am J Obstet Gynecol. 1989 Dec;161(6 Pt 2):1832-41. doi: 10.1016/s0002-9378(89)80003-1.
Three groups of indications exist for postmenopausal estrogen use: relief of symptoms related to estrogen deficiency, osteoporosis prophylaxis and treatment, and cardioprotection. Estrogen replacement therapy enhances a woman's sense of well-being and reduces the morbidity, mortality, and health care costs associated with osteoporosis and atherosclerotic heart disease. There are a few absolute contraindications to estrogen replacement therapy. Many estrogen preparations are currently available in the United States. Establishing equivalencies among the different preparations is complicated by the many physiologic and pharmacologic effects of estrogens and the variety of treatment end points used. Most estrogens have the same biologic effect provided equivalent blood levels are achieved. Estrogen replacement therapy has proved beneficial to selected postmenopausal women.
缓解与雌激素缺乏相关的症状、预防和治疗骨质疏松症以及心脏保护。雌激素替代疗法可增强女性的幸福感，并降低与骨质疏松症和动脉粥样硬化性心脏病相关的发病率、死亡率和医疗保健成本。雌激素替代疗法有一些绝对禁忌证。目前在美国有许多雌激素制剂可供使用。由于雌激素的多种生理和药理作用以及所使用的治疗终点的多样性，确定不同制剂之间的等效性很复杂。只要达到同等的血药浓度，大多数雌激素具有相同的生物学效应。雌激素替代疗法已被证明对选定的绝经后女性有益。
