Judd H L, Meldrum D R, Deftos L J, Henderson B E
Ann Intern Med. 1983 Feb;98(2):195-205. doi: 10.7326/0003-4819-98-2-195.
Estrogen replacement therapy is one of the most controversial issues in the field of reproductive medicine. Indications for its use include hot flashes, vaginal atrophy, and risk of osteoporosis. Risk of heart disease may also be an indication but this use has not been firmly established. The role of estrogen replacement therapy in aging changes of skin needs clarification. Complications of therapy include endometrial cancer, breast cancer, hypertension, hyperlipidemia, and gallbladder disease. The last three complications presumably result from hepatic actions of estrogen replacement therapy.
雌激素替代疗法是生殖医学领域最具争议的问题之一。其使用指征包括潮热、阴道萎缩和骨质疏松风险。心脏病风险也可能是一个指征，但这种用途尚未得到确凿证实。雌激素替代疗法在皮肤衰老变化中的作用需要阐明。治疗的并发症包括子宫内膜癌、乳腺癌、高血压、高脂血症和胆囊疾病。后三种并发症可能是由雌激素替代疗法的肝脏作用引起的。
