Cali R W
Postgrad Med. 1984 Mar;75(4):279-86. doi: 10.1080/00325481.1984.11697973.
The three primary indications for estrogen replacement therapy in postmenopausal women are severe vasomotor symptoms (hot flashes), prevention or treatment of osteoporosis, and atrophy of the genital tract. Estrogen replacement therapy is well established as reducing the morbidity and mortality associated with osteoporosis. The increased incidence of endometrial cancer associated with estrogen use (from 1/1,000 to 4/1,000 per year) must be accepted and viewed in perspective. Many of these estrogen-related cancers are stage I lesions, with a cure rate of 95%. In addition, the risk associated with estrogen replacement therapy can be reduced by coadministration of a progestogen during the last ten days of the cycle.
绝经后女性雌激素替代疗法的三个主要适应证是严重的血管舒缩症状（潮热）、预防或治疗骨质疏松症以及生殖道萎缩。雌激素替代疗法已被充分证实可降低与骨质疏松症相关的发病率和死亡率。必须正确看待与雌激素使用相关的子宫内膜癌发病率增加的情况（从每年1/1000增至4/1000）。许多这些与雌激素相关的癌症是I期病变，治愈率为95%。此外，在周期的最后十天同时给予孕激素可降低雌激素替代疗法相关的风险。
