Suppr超能文献

心脏手术中的颈动脉狭窄——术后结果无差异

Carotid Stenosis in Cardiac Surgery-No Difference in Postoperative Outcomes.

作者信息

Schultheis Molly, Saadat Siavash, Dombrovskiy Victor, Frenchu Kiersten, Kanduri Jaya, Romero Joseph, Lemaire Anthony, Ghaly Aziz, Bastides George, Rahimi Saum, Lee Leonard

机构信息

Department of Cardiothoracic Surgery, Rutgers Robert Wood Johnson Medical School, New Brunswick, New Jersey, United States.

Department of Vascular Surgery, Rutgers Robert Wood Johnson Medical School, New Brunswick, New Jersey, United States.

出版信息

Thorac Cardiovasc Surg. 2018 Apr;66(3):255-260. doi: 10.1055/s-0036-1571851. Epub 2016 Feb 23.

Abstract

BACKGROUND

Debate over revascularization of asymptomatic carotid stenosis before cardiac surgery is ongoing. In this study, we analyze cardiac surgery outcomes in patients with asymptomatic carotid stenosis at a single hospital.

METHODS

In this study, 1,781 patients underwent cardiac surgery from January 2012 to June 2013; 1,357 with preoperative screening carotid duplex were included. Patient demographics, comorbidities, degree of stenosis, postoperative complications, and mortality were evaluated. Chi-square test and logistic regression analysis were performed.

RESULTS

Asymptomatic stenosis was found in 403/1,357 patients (29.7%; 355 moderate and 48 severe). Patients with stenosis, compared with those without, were older (71.7 ± 11 vs. 66.3 ± 12 years;  < 0.01). Females were more likely to have stenosis (odd ratio, = 1.7; 95% confidence interval, 1.4-2.2); however, patients were predominantly male in both groups. There were no significant differences in the rates of mortality and postoperative complications, including stroke and transient ischemic attack (TIA). Postoperative TIA occurred in 3/1,357(0.2%); only one had moderate stenosis. Inhospital stroke occurred in 21/1,357 (1.5%) patients; stroke rates were 2.3% (8/355) with moderate stenosis and 2.1% (1/48) severe stenosis. There were 59/1,357 (4.3%) deaths; patients with stenosis had a mortality rate of 4.2% (17/403); however, no postoperative stroke lead to death. Multivariable logistic regression analysis with adjustment for age, gender, race, comorbidities, and postoperative complications did not show an impact of carotid stenosis on postoperative mortality and development of stroke after cardiac surgery.

CONCLUSION

This study suggests that patients with asymptomatic carotid stenosis undergoing cardiac surgery are not at increased risk of postoperative complications and mortality; thus, prophylactic carotid revascularization may not be indicated.

摘要

背景

心脏手术前无症状性颈动脉狭窄的血运重建问题仍存在争议。在本研究中,我们分析了一家医院中无症状性颈动脉狭窄患者的心脏手术结局。

方法

本研究纳入了2012年1月至2013年6月期间接受心脏手术的1781例患者;其中1357例患者术前行颈动脉双功超声筛查。评估患者的人口统计学特征、合并症、狭窄程度、术后并发症及死亡率。进行卡方检验和逻辑回归分析。

结果

1357例患者中发现403例(29.7%)存在无症状性狭窄;其中355例为中度狭窄,48例为重度狭窄。与无狭窄患者相比,有狭窄的患者年龄更大(71.7±11岁 vs. 66.3±12岁;P<0.01)。女性更易出现狭窄(比值比=1.7;95%置信区间为1.4 - 2.2);然而,两组患者均以男性为主。死亡率及包括卒中与短暂性脑缺血发作(TIA)在内的术后并发症发生率无显著差异。术后TIA发生于1357例中的3例(0.2%);仅1例为中度狭窄。住院期间卒中发生于1357例中的21例(1.5%)患者;中度狭窄患者的卒中发生率为2.3%(8/355),重度狭窄患者为2.1%(1/48)。共有1357例中的59例(4.3%)死亡;有狭窄患者的死亡率为4.2%(17/403);然而,无术后卒中导致死亡的情况。在对年龄、性别、种族、合并症及术后并发症进行校正的多变量逻辑回归分析中,未显示颈动脉狭窄对心脏手术后的术后死亡率及卒中发生有影响。

结论

本研究提示,接受心脏手术的无症状性颈动脉狭窄患者术后并发症及死亡风险并未增加;因此,可能无需进行预防性颈动脉血运重建。

文献检索

告别复杂PubMed语法,用中文像聊天一样搜索,搜遍4000万医学文献。AI智能推荐,让科研检索更轻松。

立即免费搜索

文件翻译

保留排版,准确专业,支持PDF/Word/PPT等文件格式,支持 12+语言互译。

免费翻译文档

深度研究

AI帮你快速写综述,25分钟生成高质量综述,智能提取关键信息,辅助科研写作。

立即免费体验