Swolana Denis, Kępa Małgorzata, Kabała-Dzik Agata, Dzik Radosław, Wojtyczka Robert D
Department of Microbiology and Virology, Faculty of Pharmaceutical Sciences in Sosnowiec, Medical University of Silesia in Katowice, ul. Jagiellońska 4, 41-200 Sosnowiec, Poland.
Department of Pathology, Faculty of Pharmaceutical Sciences in Sosnowiec, Medical University of Silesia in Katowice, ul. Ostrogórska 30, 41-200 Sosnowiec, Poland.
Antibiotics (Basel). 2021 May 20;10(5):607. doi: 10.3390/antibiotics10050607.
is a bacterium that belongs to the human microbiota. It is most plentiful on the skin, in the respiratory system, and in the human digestive tract. Moreover, it is the most frequently isolated microorganism belonging to the group of Coagulase Negative Staphylococci (CoNS). In recent years, it has been recognized as an important etiological factor of mainly nosocomial infections and infections related to the cardiovascular system. On the other hand, , responsible for in-hospital and out-of-hospital infections, is posing an increasing problem for clinicians due to its growing resistance to antibiotics. Biofilm produced by both of these staphylococcal species in the course of infection significantly impedes therapy. The ability to produce biofilm hinders the activity of chemotherapeutic agents-the only currently available antimicrobial therapy. This also causes the observed significant increase in bacterial resistance. For this reason, we are constantly looking for new substances that can neutralize microbial cells. In the present review, 58 substances of plant origin with antimicrobial activity against staphylococcal biofilm were replaced. Variable antimicrobial efficacy of the substances was demonstrated, depending on the age of the biofilm. An increase in the activity of the compounds occurred in proportion to increasing their concentration. Appropriate use of the potential of plant-derived compounds as an alternative to antibiotics may represent an important direction of change in the support of antimicrobial therapy.
是一种属于人类微生物群的细菌。它在皮肤、呼吸系统和人类消化道中最为丰富。此外，它是凝固酶阴性葡萄球菌（CoNS）组中最常分离出的微生物。近年来，它已被确认为主要是医院感染和与心血管系统相关感染的重要病因。另一方面，由于其对抗生素的耐药性不断增强，导致医院内和医院外感染的，给临床医生带来了越来越多的问题。这两种葡萄球菌在感染过程中产生的生物膜严重阻碍了治疗。产生生物膜的能力阻碍了化疗药物的活性——目前唯一可用的抗菌治疗方法。这也导致观察到的细菌耐药性显著增加。因此，我们一直在寻找能够中和微生物细胞的新物质。在本综述中，替换了58种对葡萄球菌生物膜具有抗菌活性的植物源物质。根据生物膜的年龄，这些物质表现出不同的抗菌效果。化合物的活性随着浓度的增加而增加。适当利用植物源化合物的潜力作为抗生素的替代品可能代表了抗菌治疗支持方面的一个重要变革方向。
