National Institute of Public Health, University of Southern Denmark, Copenhagen, Denmark.
School of Public Health, Sydney University, Sydney, New South Wales, Australia.
Br J Sports Med. 2016 Nov;50(22):1382-1387. doi: 10.1136/bjsports-2015-095648. Epub 2016 Feb 23.
To test the hypothesis that total sitting time is associated with incident diabetes, after adjustment for physical activity and obesity.
72 608 Danish adults from the DANHES cohort reported their total sitting time in 2007-2008 and were followed-up for 5 years, in relation to register-based incident diabetes mellitus. Cox regression analyses were used, and the effect-modifying influence of obesity and physical activity assessed.
The age-sex adjusted HR for developing diabetes among those who sat 10+ h/day as compared to <6 h/day was 1.35 (95% CI 1.17 to 1.57). The relative risks were similar by gender, but were largely attenuated by adjustment for potential confounding factors including physical activity, and statistically non-significant for all categories of body mass index except the obese.
The association between total sitting time and incident diabetes is substantially moderated by physical activity and obesity. Total sitting time remains a risk factor for diabetes only in inactive and obese populations.
在调整了体力活动和肥胖因素后，检验久坐总时间与新发糖尿病之间存在关联的假设。
丹麦 DANHES 队列中 72608 名成年人于 2007-2008 年报告了他们的久坐总时间，并进行了为期 5 年的随访，以观察与基于登记的新发糖尿病相关的情况。采用 Cox 回归分析，并评估肥胖和体力活动的影响。
与每天坐 6 小时以下的人相比，每天坐 10 小时以上的人发生糖尿病的年龄-性别调整后的 HR 为 1.35（95%CI 1.17-1.57）。性别之间的相对风险相似，但通过调整包括体力活动在内的潜在混杂因素，风险大大降低，除肥胖者外，所有体重指数类别均无统计学意义。
久坐总时间与新发糖尿病之间的关联受到体力活动和肥胖的显著调节。只有在不活跃和肥胖的人群中，久坐总时间仍然是糖尿病的一个危险因素。
