Department of Developmental and Cell Biology and Center for Complex Biological Systems, University of California, Irvine, CA 92697, USA.
Department of Developmental and Cell Biology and Center for Complex Biological Systems, University of California, Irvine, CA 92697, USA.
Curr Opin Cell Biol. 2016 Feb;38:45-51. doi: 10.1016/j.ceb.2016.02.006. Epub 2016 Feb 22.
Mitochondria are complex organelles with a highly regulated architecture across all levels of organization. The architecture of the inner mitochondrial membrane (IMM) provides a crucial platform for many mitochondrial functions while mitochondrial network architecture is crucial for coordinating these activities throughout the cell. This review summarizes the recent findings regarding the most important shaping factors that regulate IMM organization, how IMM architecture supports bioenergetic functions and how IMM morphology adapts to meet other physiological needs of the cell. This review also highlights recent work suggesting that the functional connectivity of mitochondrial networks can be achieved not just by matrix continuity but also by inter-mitochondrial contact sites, which generate conductive continuity within a matrix-discontinuous mitochondrial network.
线粒体是具有高度调控结构的复杂细胞器，其结构在各个组织层次上都受到严格的调控。内膜的结构为许多线粒体功能提供了关键平台，而线粒体网络结构对于协调整个细胞中的这些活动至关重要。本文综述了最近关于调节内膜组织的重要塑造因素的发现，内膜组织如何支持生物能量功能，以及内膜形态如何适应细胞的其他生理需求。本文还强调了最近的工作，表明线粒体网络的功能连接不仅可以通过基质连续性来实现，还可以通过线粒体之间的接触点来实现，这些接触点在基质不连续的线粒体网络中产生了传导连续性。
