Peres Lauren C, Camacho Fabian, Abbott Sarah E, Alberg Anthony J, Bandera Elisa V, Barnholtz-Sloan Jill, Bondy Melissa, Cote Michele L, Crankshaw Sydnee, Funkhouser Ellen, Moorman Patricia G, Peters Edward S, Schwartz Ann G, Terry Paul, Wang Frances, Schildkraut Joellen M
Department of Public Health Sciences, University of Virginia, PO Box 800765, Charlottesville, VA 22903, USA.
Hollings Cancer Center and Department of Public Health Sciences, Medical University of South Carolina, 68 President Street, Bioengineering Building 103, Charleston, SC 29425, USA.
Br J Cancer. 2016 Mar 29;114(7):819-25. doi: 10.1038/bjc.2016.39. Epub 2016 Feb 23.
Existing literature examining analgesic medication use and epithelial ovarian cancer (EOC) risk has been inconsistent, with the majority of studies reporting an inverse association. Race-specific effects of this relationship have not been adequately addressed.
Utilising data from the largest population-based case-control study of EOC in African Americans, the African American Cancer Epidemiology Study, the relationship between analgesic use (aspirin, non-aspirin nonsteroidal anti-inflammatory drugs (NSAIDs), and acetaminophen) and risk of EOC was estimated by multivariate logistic regression. The association of frequency, duration, and indication of analgesic use on EOC risk was also assessed.
Aspirin use, overall, was associated with a 44% lower EOC risk (OR=0.56; 95% CI=0.35-0.92) and a 26% lower EOC risk was observed for non-aspirin NSAID use (OR=0.74; 95% CI=0.52-1.05). The inverse association was strongest for women taking aspirin to prevent cardiovascular disease and women taking non-aspirin NSAIDs for arthritis. Significantly decreased EOC risks were observed for low-dose aspirin use, daily aspirin use, aspirin use for <5 years, and occasional non-aspirin NSAID use for a duration of ⩾5 years. No association was observed for acetaminophen use.
Collectively, these findings support previous evidence that any NSAID use is inversely associated with EOC risk.
现有研究分析止痛药物使用与上皮性卵巢癌（EOC）风险之间关系的结果并不一致，大多数研究报告称二者呈负相关。这种关系在不同种族中的影响尚未得到充分研究。
利用来自针对非裔美国人开展的最大规模基于人群的EOC病例对照研究——非裔美国人癌症流行病学研究的数据，通过多因素logistic回归分析评估止痛药物（阿司匹林、非阿司匹林非甾体抗炎药（NSAIDs）和对乙酰氨基酚）的使用与EOC风险之间的关系。同时评估了止痛药物使用的频率、持续时间和用药指征与EOC风险的关联。
总体而言，使用阿司匹林使EOC风险降低44%（OR=0.56；95%CI=0.35-0.92），使用非阿司匹林NSAIDs使EOC风险降低26%（OR=0.74；95%CI=0.52-1.05）。这种负相关在服用阿司匹林预防心血管疾病的女性以及服用非阿司匹林NSAIDs治疗关节炎的女性中最为明显。低剂量阿司匹林使用、每日使用阿司匹林、使用阿司匹林<5年以及偶尔使用非阿司匹林NSAIDs且持续时间≥5年的女性，EOC风险显著降低。未观察到对乙酰氨基酚使用与EOC风险之间存在关联。
总体而言，这些发现支持了先前的证据，即任何NSAIDs的使用均与EOC风险呈负相关。
