Department of Breast Surgery, The First Affiliated Hospital of Nanjing Medical University, 210029 Nanjing, China.
Br J Clin Pharmacol. 2013 Jan;75(1):26-35. doi: 10.1111/j.1365-2125.2012.04290.x.
Animal and in vitro studies suggest that the use of non-steroidal anti-inflammatory drugs (NSAIDs) may be associated with reduced risk for ovarian cancer. However, results from these studies have been inconsistent. The aim of our study was to review and summarize the evidence provided by longitudinal studies on the association between NSAID use and ovarian cancer risk.
A comprehensive literature search for articles published up to December 2011 was performed. Prior to performing a meta-analysis, the studies were evaluated for publication bias and heterogeneity. Relative risk (RR) or odds ratios (OR) were calculated.
Seventeen reports (13 case-control studies, one clinical trial and three cohort studies), published between 1998 and 2011 were identified. There was no evidence of an association between aspirin use and ovarian cancer risk based on a random-effects model (RR = 0.91, 95% confidence interval (CI) 0.82, 1.01) or a fixed-effects model (RR = 0.94, 95% CI 0.87, 1.01). Similarly, we did not find strong evidence of an association between non-aspirin NSAID use and ovarian cancer using a random-effects model (RR = 0.89, 95% CI 0.74, 1.08) or a fixed-effects model (RR = 0.86, 95% CI 0.76, 0.98). Furthermore, our analysis did not show a strong association between frequency or duration of non-aspirin-NSAID use and ovarian cancer.
Our findings indicate that there is no strong evidence of an association between aspirin/NA-NSAID use and ovarian cancer. However, this subject deserves further investigation.
动物和体外研究表明，使用非甾体抗炎药（NSAIDs）可能与降低卵巢癌风险有关。然而，这些研究的结果并不一致。我们的研究旨在回顾和总结关于 NSAIDs 使用与卵巢癌风险之间关联的纵向研究提供的证据。
对截至 2011 年 12 月发表的文章进行了全面的文献检索。在进行荟萃分析之前，评估了研究的发表偏倚和异质性。计算了相对风险（RR）或比值比（OR）。
共确定了 17 份报告（13 项病例对照研究、一项临床试验和三项队列研究），发表于 1998 年至 2011 年期间。基于随机效应模型（RR=0.91，95%置信区间（CI）0.82，1.01）或固定效应模型（RR=0.94，95%CI 0.87，1.01），没有发现阿司匹林使用与卵巢癌风险之间存在关联的证据。同样，我们也没有发现非阿司匹林 NSAIDs 使用与卵巢癌之间存在关联的有力证据，无论是基于随机效应模型（RR=0.89，95%CI 0.74，1.08）还是固定效应模型（RR=0.86，95%CI 0.76，0.98）。此外，我们的分析也没有显示非阿司匹林 NSAIDs 使用频率或持续时间与卵巢癌之间存在强烈关联。
我们的研究结果表明，没有强有力的证据表明阿司匹林/非阿司匹林 NSAIDs 使用与卵巢癌之间存在关联。然而，这个问题值得进一步研究。
