Faust Helena, Andersson Kristin, Luostarinen Tapio, Gislefoss Randi E, Dillner Joakim
Department of Laboratory Medicine, Division of Pathology, Karolinska Institute, Stockholm, Sweden.
Department of Occupational and Environmental Medicine, Lund University, Lund, Sweden.
Cancer Epidemiol Biomarkers Prev. 2016 Apr;25(4):721-4. doi: 10.1158/1055-9965.EPI-15-1290. Epub 2016 Feb 9.
Cutaneous human papillomavirus (HPV) types have been associated with non-melanoma skin cancer (NMSC), including a previous nested case-control study using HPV serology with bacterially derived fusion proteins with the major HPV capsid protein L1 (GST-L1). However, HPV serology using conformationally intact pseudovirions has been shown to correlate better with natural infection. Prospective studies using a more valid marker of infection are therefore warranted.
Cancer registry follow-up of large Nordic biobanks identified prediagnostic serum samples from 633 subjects who later developed SCC, 1,990 subjects who developed basal cell carcinoma (BCC). The samples from cases and matched controls were tested for IgG to pseudovirions to 16 different HPV types (3, 5, 6, 11, 15: , 16, 18, 31, 32, 33, 38: , 45, 52, 58, 68, and 76: ) and two polyomaviruses (MCPyV and JCPyV).
Baseline seropositivity was not associated with SCC risk, and there were only weak associations with BCC risk [HPV-5 (OR, 1.1; 95% confidence interval [CI], 1.0-1.3), HPV-15 (OR, 1.2; 95% CI, 1.0-1.4), HPV-38 (OR, 1.2; 95% CI, 1.0-1.3), and MCPyV (OR, 1.1; 95% CI, 1.0-1.3)]. Acquisition of HPV-5 seropositivity during follow-up was associated with SCC risk (OR, 3.2; 95% CI, 1.3-7.6). Persistent seropositivity for HPV-15 was weakly associated with BCC (OR, 1.4; 95% CI, 1.0-1.9) and HPV-6 antibody persistence was weakly associated with SCC (OR, 2.2; 95% CI, 1.0-4.8).
Considering the large number of viruses tested, the weak associations found do not support any strong links between studied HPV and NMSC, with the possible exception of HPV-5 seroconversion and SCC.
Known alpha and beta papillomaviruses do not appear to be risk factors for NMSC. Cancer Epidemiol Biomarkers Prev; 25(4); 721-4. ©2016 AACR.
皮肤人乳头瘤病毒（HPV）类型与非黑色素瘤皮肤癌（NMSC）相关，包括先前一项使用HPV血清学检测细菌衍生的主要HPV衣壳蛋白L1融合蛋白（GST-L1）的巢式病例对照研究。然而，使用构象完整的假病毒进行的HPV血清学检测已显示与自然感染的相关性更好。因此，有必要开展使用更有效感染标志物的前瞻性研究。
对大型北欧生物样本库的癌症登记随访确定了633名后来发生鳞状细胞癌（SCC）患者以及1990名发生基底细胞癌（BCC）患者的诊断前血清样本。对病例组和匹配对照组的样本检测针对16种不同HPV类型（3、5、6、11、15、16、18、31、32、33、38、45、52、58、68和76）以及两种多瘤病毒（MCPyV和JCPyV）假病毒的IgG。
基线血清阳性与SCC风险无关，与BCC风险仅有微弱关联[HPV-5（比值比[OR]，1.1；95%置信区间[CI]，1.0-1.3）、HPV-15（OR，1.2；95%CI，1.0-1.4）、HPV-38（OR，1.2；95%CI，1.0-1.3）和MCPyV（OR，1.1；95%CI，1.0-1.3）]。随访期间获得HPV-5血清阳性与SCC风险相关（OR，3.2；95%CI，1.3-7.6）。HPV-15持续血清阳性与BCC有微弱关联（OR，1.4；95%CI，1.0-1.9），HPV-6抗体持续存在与SCC有微弱关联（OR，2.2；95%CI，1.0-4.8）。
考虑到检测的病毒数量众多，所发现的微弱关联并不支持所研究的HPV与NMSC之间存在任何强关联，HPV-5血清转化与SCC可能除外。
已知的α和β乳头瘤病毒似乎不是NMSC的风险因素。《癌症流行病学、生物标志物与预防》；25(4)；721-724。©2016美国癌症研究协会。
