Hampras Shalaka S, Rollison Dana E, Giuliano Anna R, McKay-Chopin Sandrine, Minoni Lucia, Sereday Karen, Gheit Tarik, Tommasino Massimo
Department of Cancer Epidemiology.
Center for Infection Research in Cancer, Moffitt Cancer Center, Tampa, Florida.
J Infect Dis. 2017 Jul 1;216(1):92-96. doi: 10.1093/infdis/jix245.
Cutaneous beta human papillomavirus (HPV) infection across cutaneous and mucosal tissues within individuals has not been examined.
A subcohort of men (n = 87) participating in the HPV Infection in Men (HIM) study provided eyebrow hairs, forearm skin swabs, genital skin swabs, oral rinse samples, and anal swabs. Beta-HPV DNA in the 5 tissues was detected using a multiplex assay, and site-specific beta-HPV prevalence was examined.
Any beta-HPV was most prevalent in genital skin (81.6%), followed by forearm skin (64.4%), eyebrow hairs (60.9%), oral mucosa (35.6%), and anal mucosa (33.3%). Most prevalent beta-HPV types included HPV-38 (beta-2) in both genital skin (32.2%) and eyebrow hairs (16.1%), HPV-12 (beta-1) in forearm skin (23%) and oral mucosa (9.2%), and HPV-76 (beta-3) in anal mucosa (14.9%). Concordance of any beta-HPV infection was greater (31.0%) across the 3 keratinized tissue sites (genital skin, eyebrow hairs, forearm skin) than across the 2 mucosal sites (anal and oral mucosa, 6.9%).
Prevalence of beta-HPV varied by anatomic site of infection. Biological properties of beta-HPV types detected at mucosal sites and their role in disease pathogenesis should be examined.
尚未对个体皮肤和黏膜组织中的皮肤β型人乳头瘤病毒（HPV）感染情况进行研究。
参与男性HPV感染（HIM）研究的一个男性亚组（n = 87）提供了眉毛、前臂皮肤拭子、生殖器皮肤拭子、口腔冲洗样本和肛门拭子。使用多重检测法检测5种组织中的β-HPV DNA，并检查特定部位的β-HPV流行率。
任何β-HPV在生殖器皮肤中最为常见（81.6%），其次是前臂皮肤（64.4%）、眉毛（60.9%）、口腔黏膜（35.6%）和肛门黏膜（33.3%）。最常见的β-HPV类型包括生殖器皮肤（32.2%）和眉毛（16.1%）中的HPV-38（β-2）、前臂皮肤（23%）和口腔黏膜（9.2%）中的HPV-12（β-1）以及肛门黏膜（14.9%）中的HPV-76（β-3）。任何β-HPV感染在3个角化组织部位（生殖器皮肤、眉毛、前臂皮肤）之间的一致性（31.0%）高于在2个黏膜部位（肛门和口腔黏膜，6.9%）之间的一致性。
β-HPV的流行率因感染的解剖部位而异。应检查在黏膜部位检测到的β-HPV类型的生物学特性及其在疾病发病机制中的作用。
