Slavkin H C
Adv Dent Res. 1989 May;3(1):42-57. doi: 10.1177/08959374890030010401.
The introduction of recombinant DNA technology has led to a rapid advancement of our knowledge of genes and genomic structure. Such technology, applied to the human genome, has provided valuable information concerning the nature and possible treatment of inherited disorders throughout the human life span. A number of oral diseases can be attacked by use of molecular biological techniques in conjunction with genetic linkage analysis. It will be possible to identify carriers of inherited diseases, to utilize prenatal and antenatal diagnosis when appropriate, and to pursue studies on the mode of inheritance of specific oral diseases. Present and projected advances in this dimension of dental research provide the knowledge and strategies for approaching and solving a number of major problems as we continue to pave the way for improvements in the diagnosis, treatment, and prevention of many oral and craniofacial diseases. This position paper examines a few of the promising areas and suggests future goals toward establishing a knowledge of the genetic determinants for oral diseases.
重组DNA技术的引入使我们对基因和基因组结构的认识迅速进步。这项应用于人类基因组的技术，为我们提供了有关遗传性疾病在人类整个生命周期中的本质及可能治疗方法的宝贵信息。通过结合分子生物学技术与基因连锁分析，可以攻克多种口腔疾病。识别遗传性疾病的携带者、在适当的时候进行产前和出生前诊断以及开展特定口腔疾病遗传模式的研究都将成为可能。随着我们继续为改善许多口腔和颅面疾病的诊断、治疗及预防铺平道路，当前及预计在牙科研究这一领域取得的进展为我们提供了应对和解决一些重大问题的知识与策略。本立场文件探讨了一些有前景的领域，并提出了未来目标，旨在建立对口腔疾病遗传决定因素的认识。
