幽门螺杆菌CagL高变基序：地理多样性及与胃癌关联的全球分析

Helicobacter pylori CagL Hypervariable Motif: A Global Analysis of Geographical Diversity and Association With Gastric Cancer.

作者信息

Gorrell Rebecca J, Zwickel Nicolas, Reynolds John, Bulach Dieter, Kwok Terry

机构信息

Infection and Immunity Program Cancer Program, Monash Biomedicine Discovery Institute Department of Biochemistry and Molecular Biology Department of Microbiology.

Infection and Immunity Program Cancer Program, Monash Biomedicine Discovery Institute Department of Biochemistry and Molecular Biology.

出版信息

J Infect Dis. 2016 Jun 15;213(12):1927-31. doi: 10.1093/infdis/jiw060. Epub 2016 Feb 10.

DOI:10.1093/infdis/jiw060

PMID:26908724

Abstract

Previous studies suggest overrepresentation of particular polymorphisms within the Helicobacter pylori CagL hypervariable motif (CagLHM) in gastric cancer-associated isolates. However, these disease correlations were geographically variable and ambiguous. We compared the disease correlation of several hundred geographically diverse CagL sequences and identified 33 CagLHM sequence combinations with disparate geographical distribution, revealing substantial worldwide CagLHM diversity, particularly within Asian countries. Notably, polymorphisms E59 and I60 were significantly overrepresented, whereas D58 and E62 were underrepresented, in gastric cancer-associated H. pylori isolates worldwide. Thus, CagLHM regional diversity may contribute to the varied prevalence of H. pylori-related gastric cancer observed in diverse populations.

摘要

先前的研究表明，在与胃癌相关的幽门螺杆菌CagL高变基序（CagLHM）中，特定多态性在分离株中过度存在。然而，这些疾病相关性在地理上存在差异且不明确。我们比较了数百个地理上不同的CagL序列的疾病相关性，确定了33种具有不同地理分布的CagLHM序列组合，揭示了全球范围内CagLHM的大量多样性，特别是在亚洲国家。值得注意的是，在全球与胃癌相关的幽门螺杆菌分离株中，多态性E59和I60明显过度存在，而D58和E62则存在不足。因此，CagLHM区域多样性可能导致在不同人群中观察到的幽门螺杆菌相关胃癌的患病率有所不同。