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- 致病岛编码的IV型分泌系统的组成成分在……中的作用 。 （注：原文中“-pathogenicity island”这里的“-”不太明确其准确含义，可能是有遗漏或错误表述，整体翻译尽量贴近原文结构。）

Roles of the components of the -pathogenicity island encoded type IV secretion system in .

作者信息

Gou Lingzhu, Yang Xiaoping, Yun Jianwei, Ma Zenghui, Zheng Xiaofeng, Du Hongwei, Zhang Dekui

机构信息

Department of Gastroenterology, Lanzhou University Second Hospital, Lanzhou, People's Republic of China.

Department of Gastroenterology, Key Laboratory of Digestive Diseases of Lanzhou University Second Hospital, Lanzhou, People's Republic of China.

出版信息

Future Microbiol. 2024;19(14):1253-1267. doi: 10.1080/17460913.2024.2383514. Epub 2024 Aug 22.

DOI:10.1080/17460913.2024.2383514
PMID:39171625
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC11633423/
Abstract

The () cytotoxin-associated gene pathogenicity island (PAI) encodes 31 genes that assemble the type IV secretion system (T4SS) apparatus, which includes structures such as the outer membrane core complex, periplasmic ring, inner membrane complex and bacterial hairs. These proteins interact with each other to inject CagA into the host gastric epithelium. There are also individual unique functions that help interfere with host cellular pathways, modulate the immune response and colonize the host for a long time. However, the functions of some of the proteins remain unclear. This review summarizes what is known about the structure and function of these auxiliary components and discusses their role in pathogenesis.

摘要

（）细胞毒素相关基因致病岛（PAI）编码31个基因，这些基因组装成IV型分泌系统（T4SS）装置，该装置包括外膜核心复合物、周质环、内膜复合物和菌毛等结构。这些蛋白质相互作用，将CagA注入宿主胃上皮细胞。还有一些独特的功能有助于干扰宿主细胞途径、调节免疫反应并长期在宿主体内定植。然而，其中一些蛋白质的功能仍不清楚。本综述总结了关于这些辅助成分的结构和功能的已知信息，并讨论了它们在发病机制中的作用。

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