Kotb Shady, Detappe Alexandre, Lux François, Appaix Florence, Barbier Emmanuel L, Tran Vu-Long, Plissonneau Marie, Gehan Hélène, Lefranc Florence, Rodriguez-Lafrasse Claire, Verry Camille, Berbeco Ross, Tillement Olivier, Sancey Lucie
1. Institut Lumière Matière, UMR5306, Université Claude Bernard Lyon1-CNRS, Université de Lyon 69622 Villeurbanne Cedex, France.
1. Institut Lumière Matière, UMR5306, Université Claude Bernard Lyon1-CNRS, Université de Lyon 69622 Villeurbanne Cedex, France; 2. Department of Radiation Oncology, Brigham and Women's Hospital, Dana-Farber Cancer Institute and Harvard Medical School, Boston, MA, United States; 3. Nano-H, St Quentin Fallavier, 38070, France.
Theranostics. 2016 Jan 20;6(3):418-27. doi: 10.7150/thno.14018. eCollection 2016.
Nanoparticles containing high-Z elements are known to boost the efficacy of radiation therapy. Gadolinium (Gd) is particularly attractive because this element is also a positive contrast agent for MRI, which allows for the simultaneous use of imaging to guide the irradiation and to delineate the tumor. In this study, we used the Gd-based nanoparticles, AGuIX®. After intravenous injection into animals bearing B16F10 tumors, some nanoparticles remained inside the tumor cells for more than 24 hours, indicating that a single administration of nanoparticles might be sufficient for several irradiations. Combining AGuIX® with radiation therapy increases tumor cell death, and improves the life spans of animals bearing multiple brain melanoma metastases. These results provide preclinical proof-of-concept for a phase I clinical trial.
已知含有高原子序数元素的纳米颗粒可提高放射治疗的疗效。钆（Gd）特别具有吸引力，因为该元素也是磁共振成像（MRI）的阳性造影剂，这使得可以同时利用成像来引导照射并勾勒肿瘤轮廓。在本研究中，我们使用了基于钆的纳米颗粒AGuIX®。将其静脉注射到患有B16F10肿瘤的动物体内后，一些纳米颗粒在肿瘤细胞内留存超过24小时，这表明单次注射纳米颗粒可能足以进行多次照射。将AGuIX®与放射治疗相结合可增加肿瘤细胞死亡，并延长患有多发性脑黑色素瘤转移的动物的寿命。这些结果为一期临床试验提供了临床前概念验证。
