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从实验室到临床实践：超小诊疗用镧系纳米颗粒的转化。

AGuIX from bench to bedside-Transfer of an ultrasmall theranostic gadolinium-based nanoparticle to clinical medicine.

机构信息

NH TherAguix SAS, Villeurbanne, France.

Univ Lyon Université Claude Bernard Lyon 1, CNRS, Institut Lumière Matière, LYON, France.

出版信息

Br J Radiol. 2019 Jan;92(1093):20180365. doi: 10.1259/bjr.20180365. Epub 2018 Sep 18.

DOI:10.1259/bjr.20180365
PMID:30226413
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC6435081/
Abstract

AGuIX are sub-5 nm nanoparticles made of a polysiloxane matrix and gadolinium chelates. This nanoparticle has been recently accepted in clinical trials in association with radiotherapy. This review will summarize the principal preclinical results that have led to first in man administration. No evidence of toxicity has been observed during regulatory toxicity tests on two animal species (rodents and monkeys). Biodistributions on different animal models have shown passive uptake in tumours due to enhanced permeability and retention effect combined with renal elimination of the nanoparticles after intravenous administration. High radiosensitizing effect has been observed with different types of irradiations and on a large number of cancer types (brain, lung, melanoma, head and neck…). The review concludes with the second generation of AGuIX nanoparticles and the first preliminary results on human.

摘要

AGuIX 是一种亚 5nm 纳米颗粒，由聚硅氧烷基质和钆螯合物组成。这种纳米颗粒最近已被用于与放射治疗相关的临床试验。本综述将总结主要的临床前结果，这些结果导致了首次人体给药。在对两种动物（啮齿动物和猴子）进行的监管毒性试验中，没有观察到毒性证据。在不同的动物模型中的生物分布表明，由于增强的通透性和保留效应，以及静脉注射后纳米颗粒的肾脏消除，被动摄取肿瘤。已经观察到不同类型的辐射和大量癌症类型（脑、肺、黑色素瘤、头颈部等）具有高放射增敏作用。本综述的结论是第二代 AGuIX 纳米颗粒和人体的初步结果。

https://cdn.ncbi.nlm.nih.gov/pmc/blobs/bb76/6435081/0be418c610a1/bjr.20180365.g014.jpg
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https://cdn.ncbi.nlm.nih.gov/pmc/blobs/bb76/6435081/0be418c610a1/bjr.20180365.g014.jpg

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