Siwek Marcin, Styczeń Krzysztof, Sowa-Kućma Magdalena, Dudek Dominika, Reczyński Witold, Szewczyk Bernadeta, Misztak Paulina, Opoka Włodzimierz, Topór-Mądry Roman, Nowak Gabriel
Zakład Zaburzeń Afektywnych, Katedra Psychiatrii UJ CM.
Pracownia Neurobiologii Pierwiastków Śladowych, Instytut Farmakologii PAN w Krakowie.
Psychiatr Pol. 2015;49(6):1277-87. doi: 10.12740/PP/OnlineFirst/42047.
Few scientific reports indicate changes in the concentration of magnesium in the blood of patients with bipolar disorder (BD). So far very little studies concerning these issues have been conducted. Therefore, the aim of this study was to evaluate the serum magnesium level in patients with bipolar disorder (in different phases of the disease) in comparison to healthy volunteers.
The study included 129 patients (58 subjects in depressive episode, 23 in manic episode and 48 patients in remission) with the diagnosis of bipolar disorder type I or II. The control group consisted of 50 healthy people. Magnesium concentration was measured using flame atomic absorption spectrometry (FAAS).
Patients with a current depressive or manic/hypomanic episode had statistically significantly elevated serum magnesium levels compared to healthy volunteers. Moreover, a positive correlation between the duration of the manic/hypomanic episode and the relapse frequency in the last year was observed. The concentration of magnesium in patients in remission was unchanged in relation to the control group.
Presented findings suggest a role of serum magnesium level as a potential state marker, reflecting the pathophysiological changes associated with acute episodes of bipolar disorder.
鲜有科学报告指出双相情感障碍（BD）患者血液中镁浓度的变化。迄今为止，针对这些问题开展的研究非常少。因此，本研究的目的是评估双相情感障碍患者（处于疾病不同阶段）与健康志愿者相比的血清镁水平。
该研究纳入了129例诊断为I型或II型双相情感障碍的患者（58例处于抑郁发作期，23例处于躁狂发作期，48例处于缓解期）。对照组由50名健康人组成。使用火焰原子吸收光谱法（FAAS）测量镁浓度。
与健康志愿者相比，当前处于抑郁或躁狂/轻躁狂发作期的患者血清镁水平在统计学上显著升高。此外，观察到躁狂/轻躁狂发作的持续时间与去年的复发频率之间存在正相关。缓解期患者的镁浓度与对照组相比没有变化。
目前的研究结果表明血清镁水平作为一种潜在的状态标志物具有一定作用，反映了与双相情感障碍急性发作相关的病理生理变化。
