Styczeń Krzysztof, Sowa-Kućma Magdalena, Dudek Dominika, Siwek Marcin, Reczyński Witold, Szewczyk Bernadeta, Misztak Paulina, Topór-Mądry Roman, Opoka Włodzimierz, Nowak Gabriel
Zakład Zaburzeń Afektywnych, Katedra Psychiatrii, UJ CM.
Pracownia Neurobiologii Pierwiastków Śladowych, Instytut Farmakologii PAN.
Psychiatr Pol. 2018 Jun 30;52(3):449-457. doi: 10.12740/PP/OnlineFirst/80069.
The aim of this study was to compare the zinc and copper concentration in the group of patients with bipolar disorder (BD) and major depressive disorder (MDD).
110 patients with the diagnosis of BD and 114 with MDD were qualified to the study. To assess the levels of microelements, the flame atomic absorption spectrometry (FAAS) was used in the case of zinc and the electrothermal atomic absorption spectrometry (ETAAS) was used in the case of copper.
There were no differences between concentration of zinc and copper in remission and depressive phase between patients with BD and MDD. Additionally, there were also no statistically significant differences in comparisons including type I and II, early or late phase of BD and MDD.
The lack of differences in zinc and copper concentrations between patients with bipolar disorder and major depressive disorder might indicate that those disorders have similar etiology.
本研究旨在比较双相情感障碍（BD）患者组和重度抑郁症（MDD）患者组中锌和铜的浓度。
110例诊断为BD的患者和114例诊断为MDD的患者纳入本研究。为评估微量元素水平，锌的检测采用火焰原子吸收光谱法（FAAS），铜的检测采用电热原子吸收光谱法（ETAAS）。
BD患者和MDD患者在缓解期和抑郁期的锌和铜浓度无差异。此外，在包括BD和MDD的I型和II型、早期或晚期阶段的比较中，也没有统计学上的显著差异。
双相情感障碍患者和重度抑郁症患者之间锌和铜浓度缺乏差异可能表明这些疾病具有相似的病因。
