Hensel Nao, Zabel Sonja, Hensel Patrick
Tierdermatologie Basel, Emil Frey-Strasse 127, CH-4142, Münchenstein, Switzerland.
College of Veterinary Medicine, University of Georgia, 501 D. W. Brooks Drive, Athens, GA, 30602, USA.
Vet Dermatol. 2016 Apr;27(2):72-8e20. doi: 10.1111/vde.12292. Epub 2016 Feb 22.
The emergence of meticillin-resistant Staphylococcus pseudintermedius (MRSP) has become a significant animal health problem. Recent studies have indicated that previous antibacterial drug exposure is a factor in acquisition of meticillin-resistant strains of staphylococci.
HYPOTHESIS/OBJECTIVES: The purpose of this study was to identify factors associated with prior antimicrobial drug use and MRSP pyoderma in dogs presented to a veterinary teaching hospital.
Dogs diagnosed with pyoderma associated with MRSP (n = 53) or meticillin-sensitive S. pseudintermedius (MSSP; n = 45).
The medical records of dogs diagnosed with pyoderma associated with isolation of S. pseudintermedius between January 2006 and November 2012 were reviewed. All cases with a complete twelve month to 3 yr drug history prior to the diagnosis were included.
Fifty two of 53 (98%) MRSP cases and 42 of 45 (93%) MSSP cases had received at least one course of antibacterial drug prior to diagnosis. The total number of antibacterial drug prescriptions provided to pet owners and the variety of antibacterial drug classes represented were higher for cases with MRSP than for cases with MSSP (P < 0.0001 and P = 0.009, respectively). More cases with MRSP (98%) received beta-lactam drugs than those with MSSP (82%; P = 0.007) and the proportion of MRSP cases that had received concurrent immunomodulatory therapy was higher (62% versus 42%; P = 0.048).
These results suggest that the total number of antibacterial drug prescriptions, exposure to multiple drug classes (beta-lactams in particular) and concurrent immunomodulatory therapy may be associated with increased risk for acquisition of MRSP.
耐甲氧西林中间型葡萄球菌（MRSP）的出现已成为一个严重的动物健康问题。近期研究表明，先前使用抗菌药物是获得耐甲氧西林葡萄球菌菌株的一个因素。
假设/目的：本研究的目的是确定与一家兽医教学医院收治的犬类先前使用抗菌药物及MRSP脓皮病相关的因素。
诊断为与MRSP相关的脓皮病的犬（n = 53）或对甲氧西林敏感的中间型葡萄球菌（MSSP；n = 45）。
回顾了2006年1月至2012年11月期间诊断为与中间型葡萄球菌分离相关的脓皮病的犬的病历。纳入所有在诊断前有完整的12个月至3年用药史的病例。
53例MRSP病例中有52例（98%），45例MSSP病例中有42例（93%）在诊断前至少接受过一个疗程的抗菌药物治疗。提供给宠物主人的抗菌药物处方总数以及所代表的抗菌药物种类，MRSP病例比MSSP病例更多（分别为P < 0.0001和P = 0.009）。接受β-内酰胺类药物治疗的MRSP病例（98%）比MSSP病例（82%）更多（P = 0.007），且接受过同时免疫调节治疗的MRSP病例比例更高（62%对42%；P = 0.048）。
这些结果表明，抗菌药物处方总数、接触多种药物类别（尤其是β-内酰胺类）以及同时进行免疫调节治疗可能与获得MRSP的风险增加有关。
