Xydonas Sotirios, Parissis John, Lioni Louiza, Kapsimali Violetta, Psarra Ekaterini, Farmakis Dimitrios, Kremastinos Dimitrios, Lekakis John, Sideris Antonios, Tsirogianni Alexandra, Filippatos Gerasimos
aSecond Department of Cardiology bDepartment of Immunology-Histocompatibility, Evaggelismos General Hospital cHeart Failure Unit, Department of Cardiology, National and Kapodistrian University of Athens, Attikon General Hospital, Athens University dMicrobiology Department, Athens Medical School, National and Kapodistrian University of Athens, Athens, Greece.
J Cardiovasc Med (Hagerstown). 2016 Aug;17(8):624-30. doi: 10.2459/JCM.0000000000000372.
Chronic heart failure (CHF) is characterized by hemodynamic compromise, neurohormonal and immune activation. We sought to examine the presence and severity of immunosenescence and its relation with the stages of CHF.
We enrolled 86 consecutive stable systolic CHF patients and examined the relationship of leukocyte and lymphocyte subpopulation counts by flow cytometry with their functional status according to New York Heart Association (NYHA) class.
Patients with advanced heart failure were characterized by significantly increased neutrophil and reduced lymphocyte counts. T-helper cells were increased, whereas B-cells and T cytotoxic cells were decreased. T-helper cells exhibited significant differentiation and aging across the NYHA classes; naïve T-cells, CD4 + CD45RA +, were significantly reduced in NYHA Class IV and memory T-cells, CD4 + CD45RO +, were significantly increased.
Patients with CHF develop intense T-cell differentiation and aging. The presence of significant immunosenescence in advanced CHF may indicate a population at increased risk for adverse events.
慢性心力衰竭（CHF）的特征为血流动力学受损、神经激素和免疫激活。我们试图研究免疫衰老的存在及严重程度及其与CHF各阶段的关系。
我们纳入了86例连续的稳定收缩性CHF患者，并根据纽约心脏协会（NYHA）分级，通过流式细胞术检测白细胞和淋巴细胞亚群计数与其功能状态之间的关系。
晚期心力衰竭患者的特征为中性粒细胞显著增多和淋巴细胞计数减少。辅助性T细胞增多，而B细胞和细胞毒性T细胞减少。辅助性T细胞在NYHA各分级中表现出显著的分化和衰老；NYHAⅣ级患者中初始T细胞（CD4+CD45RA+）显著减少，记忆T细胞（CD4+CD45RO+）显著增加。
CHF患者会出现强烈的T细胞分化和衰老。晚期CHF中显著免疫衰老的存在可能表明这一人群发生不良事件的风险增加。
