Sangma Lucybeth N, Nath Jyoti, Bhagabati Dipesh
Department of Dermatology, Gauhati Medical College and Hospital, Guahati, Assam, India.
Department of Psychiatry, Gauhati Medical College and Hospital, Guahati, Assam, India.
Indian J Dermatol. 2015 Mar-Apr;60(2):142-6. doi: 10.4103/0019-5154.152508.
Vitiligo is an acquired discoloration of skin and mucous membrane of great cosmetic importance affecting 1-4% of the world's population. It causes disfiguration in all races, more so in dark-skinned people because of strong contrast. Men, women, and children with vitiligo face severe psychological and social disadvantage.
To assess the impact of the disease on the quality of life of patients suffering from vitiligo, also to ascertain any psychological morbidity like depression associated with the disease and to compare the results with that of healthy control group.
Dermatology Life Quality Index (DLQI) and Hamilton Depression Rating Scale (HAMD) are administered to 100 vitiligo patients presenting to the Dermatology OPD and 50 age- and sex-matched healthy controls. Results were analyzed and compared with that of control group. Findings are also correlated in relation to demographic and clinical profile of the disease. Statistical analysis is made to see the significance.
Vitiligo-affected patients had significantly elevated total DLQI scores (P < 0.001) compared to healthy controls. There is increase in parameters like itch, embarrassment, social and leisure activities in the patient cohort than the control group. Patients of vitiligo are also found to be more depressed (P < 0.001) than the controls.
Quality of life (QOL) in patients affected with vitiligo declined more severely, and also there is increase in incidence of depression than in the control group. These changes are critical for the psychosocial life of the affected people.
白癜风是一种后天性皮肤和黏膜色素脱失疾病，具有重要的美容意义，影响着全球1%-4%的人口。它在所有种族中都会导致容貌受损，在肤色较深的人群中更为明显，因为肤色对比强烈。患有白癜风的男性、女性和儿童面临着严重的心理和社会劣势。
评估该疾病对白癜风患者生活质量的影响，确定是否存在与该疾病相关的诸如抑郁等心理疾病，并将结果与健康对照组进行比较。
对前往皮肤科门诊的100例白癜风患者以及50例年龄和性别匹配的健康对照者进行皮肤病生活质量指数（DLQI）和汉密尔顿抑郁量表（HAMD）测评。对结果进行分析并与对照组进行比较。研究结果还与该疾病的人口统计学和临床特征相关联。进行统计分析以查看其显著性。
与健康对照组相比，白癜风患者的总DLQI得分显著升高（P < 0.001）。与对照组相比，患者群体在瘙痒、尴尬、社交和休闲活动等方面的参数有所增加。白癜风患者也比对照组更抑郁（P < 0.001）。
白癜风患者的生活质量（QOL）下降更为严重，而且抑郁症的发病率也高于对照组。这些变化对患者的心理社会生活至关重要。
