长链非编码RNA在癌症耐药中的调控作用

The Regulatory Role of Long Noncoding RNAs in Cancer Drug Resistance.

作者信息

Askarian-Amiri Marjan E, Leung Euphemia, Finlay Graeme, Baguley Bruce C

机构信息

Auckland Cancer Society Research Centre, Faculty of Medical and Health Sciences, University of Auckland, 85 Park Road, Grafton, Auckland, 1023, New Zealand.

Molecular Medicine and Pathology, Faculty of Medical and Health Sciences, University of Auckland, Auckland, New Zealand.

出版信息

Methods Mol Biol. 2016;1395:207-27. doi: 10.1007/978-1-4939-3347-1_12.

DOI:10.1007/978-1-4939-3347-1_12

PMID:26910076

Abstract

Recent genomic and transcriptomic analysis has revealed that the majority of the human genome is transcribed as nonprotein-coding RNA. These transcripts, known as long noncoding RNA, have structures similar to those of mRNA. Many of these transcripts are now thought to have regulatory roles in different biological pathways which provide cells with an additional layer of regulatory complexity in gene expression and proteome function in response to stimuli. A wide variety of cellular functions may thus depend on the fine-tuning of interactions between noncoding RNAs and other key molecules in cell signaling networks. Deregulation of many noncoding RNAs is thought to occur in a variety of human diseases, including neoplasia and cancer drug resistance. Here we discuss recent findings on the molecular functions of long noncoding RNAs in cellular pathways mediating resistance to anticancer drugs.

摘要

最近的基因组和转录组分析表明，人类基因组的大部分转录为非蛋白质编码RNA。这些转录本，即长链非编码RNA，其结构与mRNA相似。现在认为，其中许多转录本在不同的生物学途径中具有调控作用，这为细胞在基因表达和蛋白质组功能方面提供了额外一层的调控复杂性，以响应刺激。因此，多种细胞功能可能依赖于细胞信号网络中非编码RNA与其他关键分子之间相互作用的微调。许多非编码RNA的失调被认为发生在多种人类疾病中，包括肿瘤形成和癌症耐药性。在这里，我们讨论了长链非编码RNA在介导抗癌药物耐药性的细胞途径中的分子功能的最新发现。