Smith S S
Department of Anatomy, Hahnemann University, Philadelphia, PA 19102-1192.
Brain Res. 1989 Dec 4;503(2):354-7. doi: 10.1016/0006-8993(89)91691-0.
Ongoing studies from this laboratory have demonstrated marked potentiating actions of the sex steroid 17 beta-estradiol (E2) on glutamate-induced excitation. In the present study, systemic injection of a physiological dose of E2 was demonstrated to augment significantly excitatory responses of cerebellar Purkinje (Pnj) cells to iontophoretic application of the specific excitatory amino acid (e.a.a.) agonists quisqualate and N-methyl-D-aspartate. Potentiation of e.a.a. responses was observed as rapidly as 5-10 min post E2, and was, in many cases, a persistent, non-decremental effect. These observed long-term actions of E2 may provide one mechanism for the activating effects of the steroid on sensorimotor function and seizure activity.
本实验室正在进行的研究已证明性类固醇17β-雌二醇（E2）对谷氨酸诱导的兴奋具有显著的增强作用。在本研究中，全身注射生理剂量的E2可显著增强小脑浦肯野（Pnj）细胞对离子电渗法施加的特异性兴奋性氨基酸（e.a.a.）激动剂quisqualate和N-甲基-D-天冬氨酸的兴奋性反应。在E2注射后5-10分钟内就迅速观察到e.a.a.反应的增强，并且在许多情况下，这是一种持续的、不衰减的效应。E2的这些观察到的长期作用可能为该类固醇对感觉运动功能和癫痫活动的激活作用提供一种机制。
