Najafi Mohammadreza, Sadeghi Maedeh Mirmohamad, Mehvari Jafar, Zare Mohammad, Akbari Mojtaba
Department of Neurology, Isfahan Neuroscience Research Center, Isfahan, Iran.
Adv Biomed Res. 2013 Mar 6;2:8. doi: 10.4103/2277-9175.107974. Print 2013.
Catamenial epilepsy is a kind of epilepsy, known in this name, when the periodicity of the exacerbation of the seizure is in association with menstural cycle. The present study examined the progesterone effectiveness as a complementary treatment in women with intractable catamenial epilepsy.
The present study was conducted as a double-blind randomized controlled trial on 38 women with intractable catamenial epilepsy. Patients were assessed in two groups: The case group received in addition to AEDs, two (Mejestrol) 40 mg progesterone tablets in the second half of the cycle from 15(th) to 25(th) day. And the control group received in addition to AEDs, two placebo tablets daily. Age, BMI, epilepsy duration, types of the drugs used, progesterone level, and the number of the seizures in 3 months before and after the study were compared.
Based on the results of which there was no statistically significant difference in regard to age, BMI, epilepsy duration, types of the drugs used, progesterone level between the case and the control groups (P-value > 0.05). The number of the seizures after treatment has significantly decreased compared to before-treatment state. The degree of decreasing in the case group receiving the progesterone was higher than in the control group receiving the placebo. The difference, thus, is significant, based on statistical tests (P-value = 0.024).
Based on the findings of this study using progesterone in women with intractable catamenial epilepsy has a significant effect on the degree of decreasing in the number of the seizures.
经期性癫痫是一种癫痫类型，当癫痫发作加剧的周期性与月经周期相关时，便以此命名。本研究探讨了孕酮作为难治性经期性癫痫女性辅助治疗方法的有效性。
本研究作为一项双盲随机对照试验，对38名难治性经期性癫痫女性进行了研究。患者被分为两组进行评估：病例组在服用抗癫痫药物（AEDs）的基础上，于月经周期的后半周期（第15天至第25天）额外服用两片40毫克的孕酮片（甲地孕酮）。对照组在服用AEDs的基础上，每天额外服用两片安慰剂。比较了两组患者的年龄、体重指数（BMI）、癫痫病程、所用药物类型、孕酮水平以及研究前后3个月内的癫痫发作次数。
结果显示，病例组和对照组在年龄、BMI、癫痫病程、所用药物类型、孕酮水平方面均无统计学显著差异（P值>0.05）。与治疗前相比，治疗后癫痫发作次数显著减少。服用孕酮的病例组发作次数减少程度高于服用安慰剂的对照组。基于统计检验，二者差异显著（P值=0.024）。
基于本研究结果，孕酮对难治性经期性癫痫女性的癫痫发作次数减少程度有显著影响。
