Lawlor F, Kobza Black A, Breathnach A S, McKee P, Sarathchandra P, Bhogal B, Isaacs J L, Greaves M W, Winkelmann R K
Clin Exp Dermatol. 1989 Nov;14(6):416-20. doi: 10.1111/j.1365-2230.1989.tb02601.x.
The histopathology, immunofluorescence and ultrastructure of skin in idiopathic cold-contact urticaria have been studied over the 24 h following the application of a cold stimulus sufficient to provoke a confluent weal on the anterior thigh. Biopsies were taken 10 min, 2 h and 24 h after ice removal. Considerable epidermal and dermal oedema was present. Type I and Type II mast-cell degranulation was noted but was not universal. Lymphatics and capillaries were dilated and endothelial cells showed an increase in micropinocytotic activity, without evident vasculitis. In two cases packed platelets were seen within vessel lumina. There was no change in the infiltrating dermal cell population and direct immunofluorescence was negative. The evidence suggests that idiopathic cold-contact urticaria is an exudative rather than an infiltrative process.
在对大腿前部施加足以引发融合性风团的冷刺激后的24小时内，对特发性冷接触性荨麻疹患者的皮肤进行了组织病理学、免疫荧光和超微结构研究。在移除冰块后10分钟、2小时和24小时取活检组织。可见明显的表皮和真皮水肿。观察到I型和II型肥大细胞脱颗粒，但并非普遍现象。淋巴管和毛细血管扩张，内皮细胞的微吞饮活性增加，无明显血管炎。在两例患者的血管腔内可见聚集的血小板。浸润性真皮细胞群体无变化，直接免疫荧光为阴性。证据表明，特发性冷接触性荨麻疹是一个渗出性而非浸润性过程。
